Neuroprotective effects of mango cv. ‘Ataulfo’ peel and pulp against oxidative stress in streptozotocin-induced diabetic rats

Rosario Cázares-Camacho, J. Abraham Domínguez-Avila, Humberto Astiazarán-García, Marcelino Montiel-Herrera, Gustavo A. González-Aguilar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

BACKGROUND: Oxidative stress has been implicated in the pathogenesis and progression of diabetes mellitus. Both can damage the brain. Mango and its by-products are sources of bioactive compounds with antioxidant properties. We hypothesized that mango cv. ‘Ataulfo’ peel and pulp mitigate oxidative stress in the brain of streptozotocin-induced diabetic rats. RESULTS: Twenty-four male Wistar rats were divided into four groups: control, untreated diabetic (UD), diabetic treated with a mango-supplemented diet (MTD), and diabetic pretreated with a mango-supplemented diet (MPD). The rats were fed the different diets for 4 weeks after diabetes induction (MTD), or 2 weeks before and 4 weeks after induction (MPD). After the intervention, serum and brain (cerebellum and cortex) were collected to evaluate gene expression, enzyme activity, and redox biomarkers. Superoxide dismutase 2 (SOD2) expression increased in the cortex of the MTD group, whereas glutathione-S-transferase p1 (GSTp1) expression was higher in the cortex of the MTD group, and cortex and cerebellum of the MPD group. SOD1 activity was higher in the cerebellum and cortex of all diabetic groups, whereas GST activity increased in the cerebellum and cortex of the MPD group. Lipid peroxidation increased in the cerebellum and cortex of the UD group; however, a mango-supplemented diet prevented this increase in both regions, while also mitigating polyphagia and weight loss, and maintaining stable glycemia in diabetic rats. CONCLUSION: We propose that mango exerts potent neuroprotective properties against diabetes-induced oxidative stress. It can be an alternative to prevent and treat biochemical alterations caused by diabetes.

Original languageEnglish
Pages (from-to)497-504
Number of pages8
JournalJournal of the Science of Food and Agriculture
Volume101
Issue number2
DOIs
StatePublished - 30 Jan 2021

Bibliographical note

Funding Information:
Rosario C?zares-Camacho thanks Consejo Nacional de Ciencia y Tecnolog?a (CONACyT) for the scholarship that allowed her to obtain her master's degree. We thank CONACyT for its financial support through project Ciencia de Frontera (P00054044).

Funding Information:
Rosario Cázares‐Camacho thanks Consejo Nacional de Ciencia y Tecnología (CONACyT) for the scholarship that allowed her to obtain her master's degree. We thank CONACyT for its financial support through project Ciencia de Frontera (P00054044).

Publisher Copyright:
© 2020 Society of Chemical Industry

Keywords

  • byproducts
  • diabetes
  • neuroprotection
  • oxidative stress

Fingerprint

Dive into the research topics of 'Neuroprotective effects of mango cv. ‘Ataulfo’ peel and pulp against oxidative stress in streptozotocin-induced diabetic rats'. Together they form a unique fingerprint.

Cite this