Neutral reducing agents supported on merrifield resin obtained by solid phase organic synthesis

Milagros Aguilar-Martínez*, Judas Tadeo Vargas-Durazo, Adrián Ochoa-Terán, Hisila Santacruz-Ortega, Karen Ochoa-Lara, Arturo Zizumbo-López, Juan Carlos Gálvez-Ruíz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

An efficient methodology for the synthesis of neutral reducing agents supported on Merrifield resin has been developed. The process was carried out under mild conditions, varying the linker length, the bidentate chelating amine and the alkali metal tetrahydroborate. Fluorescence and infrared spectroscopies and thermogravimetric analysis were used for monitoring the chemical modifications. The developed methodology proved to be successful in obtaining a library of 40 neutral reducing agents supported on Merrifield resin in high yields (90–95%), with the potential to reduce carbonyl compounds and to be reusable.

Original languageEnglish
Article number132195
JournalTetrahedron
Volume91
DOIs
StatePublished - 2 Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

  • Borohydride
  • Reducing agents
  • Solid-phase organic synthesis
  • Synthesis method

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