An efficient methodology for the synthesis of neutral reducing agents supported on Merrifield resin has been developed. The process was carried out under mild conditions, varying the linker length, the bidentate chelating amine and the alkali metal tetrahydroborate. Fluorescence and infrared spectroscopies and thermogravimetric analysis were used for monitoring the chemical modifications. The developed methodology proved to be successful in obtaining a library of 40 neutral reducing agents supported on Merrifield resin in high yields (90–95%), with the potential to reduce carbonyl compounds and to be reusable.
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- Reducing agents
- Solid-phase organic synthesis
- Synthesis method