Peptide functionalized magneto-plasmonic nanoparticles obtained by microfluidics for inhibition of β-amyloid aggregation

N. Hassan; M. L. Cordero; R. Sierpe; M. Almada; J. Juárez; M. Valdez; A. Riveros; E. Vargas; A. Abou-Hassan; J. M. Ruso; M. J. Kogan

doi:10.1039/c8tb00206a

Peptide functionalized magneto-plasmonic nanoparticles obtained by microfluidics for inhibition of β-amyloid aggregation

N. Hassan^*, M. L. Cordero, R. Sierpe, M. Almada, J. Juárez, M. Valdez, A. Riveros, E. Vargas, A. Abou-Hassan, J. M. Ruso, M. J. Kogan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In the present work, we report on the synthesis of peptide functionalized magneto-plasmonic nanoparticles in a simple microfluidic platform. Superparamagnetic nanoparticles and gold nanorods were selected for this study. Magnetic nanoparticles were functionalized with peptide D1, which can bind selectively to toxic aggregates of the β-amyloid peptide associated with Alzheimer's disease. Gold nanorods were functionalized with chitosan replacing the surfactant cetyltrimethylammonium bromide to reduce the cytotoxic effect. The selected microfluidic strategy yields structures with plasmonic and magnetic properties in a nanostructure. Cytotoxic assays with SH-SY5Y cells demonstrate that nanoparticles obtained by microfluidics do not affect cell viability at the studied concentrations. Additionally, these magneto-plasmonic nanoparticles inhibit fibril formation demonstrating that the magneto-plasmonic nanoparticles obtained by microfluidics could be applied for a potential treatment and diagnosis of Alzheimer's disease.

Original language	English
Pages (from-to)	5091-5099
Number of pages	9
Journal	Journal of Materials Chemistry B
Volume	6
Issue number	31
DOIs	https://doi.org/10.1039/c8tb00206a
State	Published - 1 Jan 2018

Bibliographical note

Funding Information:
N. Hassan acknowledges funding from Programa Fondecyt Postdoctoral number 3140489 and Fondecyt de Iniciación No. 11170489. M. L. Cordero acknowledges support from Millennium Nucleus Physics of Active Matter of the Millennium Scientific Initiative of the Ministry of Economy, Development and Tourism. Microchannel fabrication was possible thanks to Conicyt, Fondequip Grant No. EQM140055. M. J. Kogan thanks Fondap 15130011 and Fondecyt 1170929. J. M. Ruso thanks MINECO (MAT2015-71826-P) and Fundación Ramón Areces for financial support. J. Juárez thanks the Consejo Nacional de Ciencia y Tecnología (CONACyT; México) for financial support through projects 236185. E. Vargas acknowledges funding from Basal FB0807 (CEDENNA).

Publisher Copyright:
This journal is © The Royal Society of Chemistry.

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abstract = "In the present work, we report on the synthesis of peptide functionalized magneto-plasmonic nanoparticles in a simple microfluidic platform. Superparamagnetic nanoparticles and gold nanorods were selected for this study. Magnetic nanoparticles were functionalized with peptide D1, which can bind selectively to toxic aggregates of the β-amyloid peptide associated with Alzheimer's disease. Gold nanorods were functionalized with chitosan replacing the surfactant cetyltrimethylammonium bromide to reduce the cytotoxic effect. The selected microfluidic strategy yields structures with plasmonic and magnetic properties in a nanostructure. Cytotoxic assays with SH-SY5Y cells demonstrate that nanoparticles obtained by microfluidics do not affect cell viability at the studied concentrations. Additionally, these magneto-plasmonic nanoparticles inhibit fibril formation demonstrating that the magneto-plasmonic nanoparticles obtained by microfluidics could be applied for a potential treatment and diagnosis of Alzheimer's disease.",

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AU - Cordero, M. L.

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AU - Almada, M.

AU - Juárez, J.

AU - Valdez, M.

AU - Riveros, A.

AU - Vargas, E.

AU - Abou-Hassan, A.

AU - Ruso, J. M.

AU - Kogan, M. J.

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AB - In the present work, we report on the synthesis of peptide functionalized magneto-plasmonic nanoparticles in a simple microfluidic platform. Superparamagnetic nanoparticles and gold nanorods were selected for this study. Magnetic nanoparticles were functionalized with peptide D1, which can bind selectively to toxic aggregates of the β-amyloid peptide associated with Alzheimer's disease. Gold nanorods were functionalized with chitosan replacing the surfactant cetyltrimethylammonium bromide to reduce the cytotoxic effect. The selected microfluidic strategy yields structures with plasmonic and magnetic properties in a nanostructure. Cytotoxic assays with SH-SY5Y cells demonstrate that nanoparticles obtained by microfluidics do not affect cell viability at the studied concentrations. Additionally, these magneto-plasmonic nanoparticles inhibit fibril formation demonstrating that the magneto-plasmonic nanoparticles obtained by microfluidics could be applied for a potential treatment and diagnosis of Alzheimer's disease.

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Peptide functionalized magneto-plasmonic nanoparticles obtained by microfluidics for inhibition of β-amyloid aggregation

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