In the present work, it was demonstrated that in amoebic dysentery and amoebic liver abscess patients, the secretory response is long-lasting (> 12 months); and 50% of amoebic dysentery patients developed circulating antiamoebic IgG in comparison with 100% of amoebic liver abscess individuals. A total of 83% of these individuals developed high levels of serum anti-Entamoeba histolytica IgA. However, only 10.4% of the dysentery patients showed this anti-E. histolytica antibody isotype in serum. There was no correlation between secretory and serum antiamoebic response, suggesting independent inductive and effector sites in both compartments.
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Acknowledgements This work was supported by grants 3065M9306 from CONACYT México and IN201695 from DGAPA UNAM México. The authors gratefully thank Mrs. Ma. Elena Ortṍ z for her secretarial assistance. All experiments and sampling comply with the current laws for research in animal and human subjects.