Persistence of secretory antiamoebic antibodies in patients with past invasive intestinal or hepatic amoebiasis

Olivia Valenzuela, Fernando Ramos, Patricia Morán, Enrique González, Alicia Valadez, Alejandro Gómez, Emma I. Melendro, Manuel Ramiro, Onofre Muñoz, Cecilia Ximénez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

In the present work, it was demonstrated that in amoebic dysentery and amoebic liver abscess patients, the secretory response is long-lasting (> 12 months); and 50% of amoebic dysentery patients developed circulating antiamoebic IgG in comparison with 100% of amoebic liver abscess individuals. A total of 83% of these individuals developed high levels of serum anti-Entamoeba histolytica IgA. However, only 10.4% of the dysentery patients showed this anti-E. histolytica antibody isotype in serum. There was no correlation between secretory and serum antiamoebic response, suggesting independent inductive and effector sites in both compartments.

Original languageEnglish
Pages (from-to)849-852
Number of pages4
JournalParasitology Research
Volume87
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements This work was supported by grants 3065M9306 from CONACYT México and IN201695 from DGAPA UNAM México. The authors gratefully thank Mrs. Ma. Elena Ortṍ z for her secretarial assistance. All experiments and sampling comply with the current laws for research in animal and human subjects.

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