PH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(c-glutamic acid) as amoxicillin controlled-release system

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA)with different proportionswere studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final release of amoxicillin were determined in batch experiments.The release kinetic testswere conducted using a buffer solution as the release medium under pHconditions of 3 and 7.2, and temperature of 25, 37, and 45 °C. The final percentage of amoxicillin released from the hydrogels was found to increase with temperature, pH, and the amount of γ-PGA in the hydrogels formulation. Overall, equilibrium conditions in the kinetics experiments were achieved within 240 min of hydrogel-solution contact.The overall rate of amoxicillin releasewas represented with a two-parameter empirical model as a function of time. © 2011 Springer-Verlag.
Original languageEnglish
Pages (from-to)197-207
Number of pages11
JournalPolymer Bulletin
Volume68
Issue number1
DOIs
StatePublished - Jan 2012

Bibliographical note

Cited By :9

Export Date: 23 April 2019

CODEN: POBUD

Correspondence Address: Rodríguez-Félix, D.E.; Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Colonia Centro, Rosales y Luis Encinas s/n, Hermosillo, Sonora 83000, Mexico; email: dora@polimeros.uson.mx

References: Risbud, M.V., Hardikar, A.A., Bhat, S.V., Bhonde, R.R., PH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery (2000) Journal of Controlled Release, 68 (1), pp. 23-30. , DOI 10.1016/S0168-3659(00)00208-X, PII S016836590000208X; Liu, Z., Lu, W., Qian, L., Zhang, X., Zeng, P., Pan, J., In vitro and in vivo studies on mucoadhesive microspheres of amoxicillin (2005) Journal of Controlled Release, 102 (1), pp. 135-144. , DOI 10.1016/j.jconrel.2004.06.022, PII S0168365904003189; Santos, D.P., Bergamini, M.F., Zanoni, M.V., Voltammetric sensor for amoxicillin determination in human urine using polyglutamic acid/glutaraldehyde film (2008) Sens Actuators B Chem, 133, pp. 398-403; Liu, J., Lin, S., Li, L., Liu, E., Release of theophylline from polymer blend hydrogels (2005) International Journal of Pharmaceutics, 298 (1), pp. 117-125. , DOI 10.1016/j.ijpharm.2005.04.006, PII S0378517305002292; Huang, Y., Yu, H., Xiao, C., PH-sensitive cationic guar gum/poly (acrylic acid) polyelectrolyte hydrogels: Swelling and in vitro drug release (2007) Carbohydrate Polymers, 69 (4), pp. 774-783. , DOI 10.1016/j.carbpol.2007.02.016, PII S0144861707001269; Zhao, Y., Kang, J., Tan, T., Salt-, pH- and temperature-responsive semi-interpenetrating polymer network hydrogel based on poly(aspartic acid) and poly(acrylic acid) (2006) Polymer, 47 (22), pp. 7702-7710. , DOI 10.1016/j.polymer.2006.08.056, PII S0032386106010068; Caykara, T., Sengul, G., Birlik, G., Preparation and swelling properties of temperature-sensitive semi-interpenetrating polymer networks composed of poly[(N-tert-butylacrylamide) -co-acrylamide] and hydroxypropyl cellulose (2006) Macromolecular Materials and Engineering, 291 (9), pp. 1044-1051. , DOI 10.1002/mame.200600063; Rodŕguez, D.E., Romero-Garća, J., Ramirez-Vargas, E., Ledezma-Pérez, A.S., Arias-Maŕn, E., Synthesis and swelling characteristics of semi-interpenetrating polymer network hydrogels composed ofpoly(acrylamide) and poly(y-glutamic acid (2006) Mater Lett, 60, pp. 1390-1393; Gonzales, D., Fan, K., Sevoian, M., Synthesis and swelling characterizations of a poly(gamma-glutamic acid) hydrogel (1996) Journal of Polymer Science, Part A: Polymer Chemistry, 34 (10), pp. 2019-2027; Rodŕguez-Félix De, C., Synthesis and swelling properties of p H- and temperature sensitive interpenetrating polymer networks composed of poly(acrylamide) and poly(y-glutamic acid) (2011) J Appl Polym Sci, 119, pp. 3531-3537; Ritger, P.L., Peppas, N.A., A simple equation for desciption of solute release I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs (1987) Journal of Controlled Release, 5 (1), pp. 23-36. , DOI 10.1016/0168-3659(87)90034-4; Ritger, P.L., Peppas, N.A., A simple equation for description of solute release II. Fickian and anomalous release from swellable devices (1987) Journal of Controlled Release, 5 (1), pp. 37-42. , DOI 10.1016/0168-3659(87)90035-6; Siepmann, J., Peppas, N.A., Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC) (2001) Advanced Drug Delivery Reviews, 48 (2-3), pp. 139-157. , DOI 10.1016/S0169-409X(01)00112-0, PII S0169409X01001120

Keywords

  • Amoxicillin controlled release
  • Poly(acrylamide)
  • Poly(c-glutamic acid)
  • Polymer gels
  • Semi-interpenetrating networks
  • Amoxicillin
  • Buffer solutions
  • Controlled release
  • Empirical model
  • Equilibrium conditions
  • Function of time
  • Glutamic acid
  • Kinetics experiments
  • Overall rate
  • Release kinetics
  • Temperature-Sensitive
  • Amides
  • Amino acids
  • Interpenetrating polymer networks
  • Kinetics
  • pH effects
  • Hydrogels

Fingerprint

Dive into the research topics of 'PH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(c-glutamic acid) as amoxicillin controlled-release system'. Together they form a unique fingerprint.

Cite this