PH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(c-glutamic acid) as amoxicillin controlled-release system

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Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA)with different proportionswere studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final release of amoxicillin were determined in batch experiments.The release kinetic testswere conducted using a buffer solution as the release medium under pHconditions of 3 and 7.2, and temperature of 25, 37, and 45 °C. The final percentage of amoxicillin released from the hydrogels was found to increase with temperature, pH, and the amount of γ-PGA in the hydrogels formulation. Overall, equilibrium conditions in the kinetics experiments were achieved within 240 min of hydrogel-solution contact.The overall rate of amoxicillin releasewas represented with a two-parameter empirical model as a function of time. © 2011 Springer-Verlag.
Original languageEnglish
Pages (from-to)197-207
Number of pages11
JournalPolymer Bulletin
Issue number1
StatePublished - Jan 2012

Bibliographical note

Cited By :9

Export Date: 23 April 2019


Correspondence Address: Rodríguez-Félix, D.E.; Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Colonia Centro, Rosales y Luis Encinas s/n, Hermosillo, Sonora 83000, Mexico; email:

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  • Amoxicillin controlled release
  • Poly(acrylamide)
  • Poly(c-glutamic acid)
  • Polymer gels
  • Semi-interpenetrating networks
  • Amoxicillin
  • Buffer solutions
  • Controlled release
  • Empirical model
  • Equilibrium conditions
  • Function of time
  • Glutamic acid
  • Kinetics experiments
  • Overall rate
  • Release kinetics
  • Temperature-Sensitive
  • Amides
  • Amino acids
  • Interpenetrating polymer networks
  • Kinetics
  • pH effects
  • Hydrogels


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