Phenolic compounds that cross the blood-brain barrier exert positive health effects as central nervous system antioxidants

Dafne Velásquez-Jiménez, Diana A. Corella-Salazar, B. Shain Zuñiga-Martínez, J. Abraham Domínguez-Avila*, Marcelino Montiel-Herrera, Norma J. Salazar-López, Joaquín Rodrigo-Garcia, Mónica A. Villegas-Ochoa, Gustavo A. González-Aguilar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The blood-brain barrier (BBB) is a physical structure whose main function is to strictly regulate access to circulating compounds into the central nervous system (CNS). Vegetable-derived phenolic compounds have been widely studied, with numerous epidemiologic and interventional studies confirming their health-related bioactivities across multiple cells, organs and models. Phenolics are non-essential xenobiotics, and should theoretically be unable to cross the BBB. The present work summarizes current experimental evidence that reveals that not only are phenolic compounds able to cross the BBB and bioaccumulate in the brain, but there is some stereoselectivity, which suggests the presence of specific transporters that allow them to reach the brain. Some molecules cross the BBB intact, while others do so only after being biotransformed or metabolized elsewhere. Once inside the CNS, they prevent or counter oxidative stress, which maintains the molecular, cellular, structural and functional integrity of the brain, and subsequently, overall human health.

Original languageEnglish
Pages (from-to)10356-10369
Number of pages14
JournalFood and Function
Issue number21
StatePublished - 7 Nov 2021

Bibliographical note

Funding Information:
This work was supported by Instituto de Bebidas de la Industria Mexicana de Coca-Cola through project “Inducción de saciedad y modulación de la digestión intestinal de lípidos ejercidos por los compuestos fenólicos de aguacate Hass” (Premio Nacional en Ciencia y Tecnología de Alimentos 2019) and by Centro de Investigación en Alimentación y Desarrollo (CIAD) A. C.

Publisher Copyright:
© 2021 The Royal Society of Chemistry.


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