Phosphatase-triggered guest release from a cyclodextrin complex

Cho Arthur, Karen L. Ochoa Lara, Anatoly K. Yatsimirsky*, Alexey V. Eliseev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


(matrix presented) A synthetic supramolecular system is described that models the effect of phosphoryl transfer in molecular recognition. β-Cyclodextrin-6A-phosphate (pCD), which is shown to be a substrate of alkaline phosphatase, binds cationic aromatic guests, including anticancer agents, up to 100-fold better than native β-CD. The above observations demonstrate that pCD is capable of releasing the guests from its cavity upon hydrolysis with the phosphatase, as also confirmed by monitoring the hydrolysis in the presence of a guest.

Original languageEnglish
Pages (from-to)1741-1743
Number of pages3
JournalOrganic Letters
Issue number12
StatePublished - 15 Jun 2000
Externally publishedYes


Dive into the research topics of 'Phosphatase-triggered guest release from a cyclodextrin complex'. Together they form a unique fingerprint.

Cite this