Polyurethane electrospun membranes with hydroxyapatite-vancomycin for potential application in bone tissue engineering and drug delivery

Claudia Vásquez-López, Maria Monica Castillo-Ortega*, Lerma Hanaiy Chan-Chan, Irlanda Lagarda-Díaz, Astrid Lorena Giraldo-Betancur, Dora Evelia Rodríguez-Félix, José Carmelo Encinas Encinas, Maria Elisa Martínez-Barbosa, Gregorio Cadenas-Pliego, Juan Valerio Cauich-Rodríguez, Pedro Jesus Herrera-Franco

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study is to evaluate the drug delivery behavior and other properties of electrospun composite membranes for potential use in tissue engineering. Tecoflex® (PU1), and a lab-made polyurethane (PU2) were studied. They were mixed with nano-hydroxyapatite (PU1-nHA and PU2-nHA) and vancomycin (PU1-VA and PU2-VA) or mixed with both, nHA and VA (PU1-nHA-VA and PU2-nHA-VA). Scanning electron microscopy showed a porous structure in all the electrospun membranes with smooth fibers in PU1 and its composites with sizes in the range of 0.6–0.9 μm and nanoparticles of HA, both, adhered and embedded on the PU fibers were observed. nHA and VA affected the thermal and mechanical behavior of composites. Elastic modulus, cytotoxicity, and kinetic release were affected by the PU and nHA. Cell viability up to 75% showed that all membrane extracts are not cytotoxic while microbial inhibition activity was observed in PU1-VA, PU1-nHA-VA, and PU2-VA.

Original languageEnglish
Article number51893
JournalJournal of Applied Polymer Science
Volume139
Issue number14
DOIs
StatePublished - 10 Apr 2022

Bibliographical note

Funding Information:
The author C. Vásquez‐López thanks the Consejo Nacional de Ciencia y Tecnología for grant 637410 scholarship to develop this project. Special thanks to: Silvia Elena Burruel‐Ibarra collaborated in the SEM analysis and their explanation. Damian Francisco Plascencia‐Martínez, collaborated in the thermal properties experiments and performed TGA experiments. Javier Iván Cauich‐Cupul, collaborated in the mechanical stress tests and their explanation. Hugo Joel Carrillo‐Escalante, prepared additional materials during the research stay at Scientific Research Center de Yucatán. Rossana Vargas‐Coronado collaborated in cell viability tests.

Publisher Copyright:
© 2021 Wiley Periodicals LLC.

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