TY - JOUR
T1 - Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production
AU - Flores-Mendoza, Lilian
AU - Silva-Campa, Erika
AU - Reséndiz, Mónica
AU - Osorio, Fernando A.
AU - Hernández, Jesús
PY - 2008/4
Y1 - 2008/4
N2 - Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.
AB - Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.
UR - http://www.scopus.com/inward/record.url?scp=47049098221&partnerID=8YFLogxK
U2 - 10.1128/CVI.00224-07
DO - 10.1128/CVI.00224-07
M3 - Artículo
SN - 1556-6811
VL - 15
SP - 720
EP - 725
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 4
ER -