Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production

Lilian Flores-Mendoza, Erika Silva-Campa, Mónica Reséndiz, Fernando A. Osorio, Jesús Hernández*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.

Original languageEnglish
Pages (from-to)720-725
Number of pages6
JournalClinical and Vaccine Immunology
Volume15
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

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