Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin

D. E. Rodríguez-Félix; M. M. Castillo-Ortega; A. L. Nájera-Luna; A. G. Montaño-Figueroa; I. Y. López-Peña; T. Del Castillo-Castro; F. Rodríguez-Félix; J. M. Quiroz-Castillo; P. J. Herrera-Franco

doi:10.2174/1567201813666151204121752

Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin

D. E. Rodríguez-Félix, M. M. Castillo-Ortega^*, A. L. Nájera-Luna, A. G. Montaño-Figueroa, I. Y. López-Peña, T. Del Castillo-Castro, F. Rodríguez-Félix, J. M. Quiroz-Castillo, P. J. Herrera-Franco

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The optimal conditions for the fibers preparation of cellulose acetate (CA) and poly(vinyl pyrrolidone) (PVP) containing triclosan within the fiber were successfully found; the physicochemical characteristics of these fibrous membranes were corroborated by FTIR spectroscopy, thermal analysis, mechanical tests, SEM , and TEM analysis. The formation of composite fibers of CA and PVP containing triclosan at the core of the fiber was evidenced. A comparative study of the release properties of amoxicillin, epicatechin or triclosan embedded into fibers CA/PVP/CA was performed. As more interactions of the drug with CA or PVP occur, slower release of the drug into the release medium takes place. Regarding the drug delivery system design, it is important to consider the possible molecular interactions between the material components and predict how fast or slow the drug will be delivered into the corresponding medium.

Original language	English
Pages (from-to)	49-56
Number of pages	8
Journal	Current Drug Delivery
Volume	13
Issue number	1
DOIs	https://doi.org/10.2174/1567201813666151204121752
State	Published - 1 Feb 2016

Bibliographical note

Publisher Copyright:
© 2016 Bentham Science Publishers.

Keywords

Amoxicillin
Epicatechin
Molecular interactions
Release
System design
Triclosan

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Rodríguez-Félix, D. E., Castillo-Ortega, M. M., Nájera-Luna, A. L., Montaño-Figueroa, A. G., López-Peña, I. Y., Del Castillo-Castro, T., Rodríguez-Félix, F., Quiroz-Castillo, J. M., & Herrera-Franco, P. J. (2016). Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin. Current Drug Delivery, 13(1), 49-56. https://doi.org/10.2174/1567201813666151204121752

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title = "Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin",

abstract = "The optimal conditions for the fibers preparation of cellulose acetate (CA) and poly(vinyl pyrrolidone) (PVP) containing triclosan within the fiber were successfully found; the physicochemical characteristics of these fibrous membranes were corroborated by FTIR spectroscopy, thermal analysis, mechanical tests, SEM , and TEM analysis. The formation of composite fibers of CA and PVP containing triclosan at the core of the fiber was evidenced. A comparative study of the release properties of amoxicillin, epicatechin or triclosan embedded into fibers CA/PVP/CA was performed. As more interactions of the drug with CA or PVP occur, slower release of the drug into the release medium takes place. Regarding the drug delivery system design, it is important to consider the possible molecular interactions between the material components and predict how fast or slow the drug will be delivered into the corresponding medium.",

keywords = "Amoxicillin, Epicatechin, Molecular interactions, Release, System design, Triclosan",

author = "Rodr{\'i}guez-F{\'e}lix, {D. E.} and Castillo-Ortega, {M. M.} and N{\'a}jera-Luna, {A. L.} and Monta{\~n}o-Figueroa, {A. G.} and L{\'o}pez-Pe{\~n}a, {I. Y.} and {Del Castillo-Castro}, T. and F. Rodr{\'i}guez-F{\'e}lix and Quiroz-Castillo, {J. M.} and Herrera-Franco, {P. J.}",

note = "Publisher Copyright: {\textcopyright} 2016 Bentham Science Publishers.",

year = "2016",

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day = "1",

doi = "10.2174/1567201813666151204121752",

language = "Ingl{\'e}s",

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Rodríguez-Félix, DE, Castillo-Ortega, MM, Nájera-Luna, AL, Montaño-Figueroa, AG, López-Peña, IY, Del Castillo-Castro, T, Rodríguez-Félix, F, Quiroz-Castillo, JM & Herrera-Franco, PJ 2016, 'Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin', Current Drug Delivery, vol. 13, no. 1, pp. 49-56. https://doi.org/10.2174/1567201813666151204121752

Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin. / Rodríguez-Félix, D. E.; Castillo-Ortega, M. M.; Nájera-Luna, A. L. et al.
In: Current Drug Delivery, Vol. 13, No. 1, 01.02.2016, p. 49-56.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin

AU - Rodríguez-Félix, D. E.

AU - Castillo-Ortega, M. M.

AU - Nájera-Luna, A. L.

AU - Montaño-Figueroa, A. G.

AU - López-Peña, I. Y.

AU - Del Castillo-Castro, T.

AU - Rodríguez-Félix, F.

AU - Quiroz-Castillo, J. M.

AU - Herrera-Franco, P. J.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - The optimal conditions for the fibers preparation of cellulose acetate (CA) and poly(vinyl pyrrolidone) (PVP) containing triclosan within the fiber were successfully found; the physicochemical characteristics of these fibrous membranes were corroborated by FTIR spectroscopy, thermal analysis, mechanical tests, SEM , and TEM analysis. The formation of composite fibers of CA and PVP containing triclosan at the core of the fiber was evidenced. A comparative study of the release properties of amoxicillin, epicatechin or triclosan embedded into fibers CA/PVP/CA was performed. As more interactions of the drug with CA or PVP occur, slower release of the drug into the release medium takes place. Regarding the drug delivery system design, it is important to consider the possible molecular interactions between the material components and predict how fast or slow the drug will be delivered into the corresponding medium.

AB - The optimal conditions for the fibers preparation of cellulose acetate (CA) and poly(vinyl pyrrolidone) (PVP) containing triclosan within the fiber were successfully found; the physicochemical characteristics of these fibrous membranes were corroborated by FTIR spectroscopy, thermal analysis, mechanical tests, SEM , and TEM analysis. The formation of composite fibers of CA and PVP containing triclosan at the core of the fiber was evidenced. A comparative study of the release properties of amoxicillin, epicatechin or triclosan embedded into fibers CA/PVP/CA was performed. As more interactions of the drug with CA or PVP occur, slower release of the drug into the release medium takes place. Regarding the drug delivery system design, it is important to consider the possible molecular interactions between the material components and predict how fast or slow the drug will be delivered into the corresponding medium.

KW - Amoxicillin

KW - Epicatechin

KW - Molecular interactions

KW - Release

KW - System design

KW - Triclosan

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U2 - 10.2174/1567201813666151204121752

DO - 10.2174/1567201813666151204121752

M3 - Artículo

SN - 1567-2018

VL - 13

SP - 49

EP - 56

JO - Current Drug Delivery

JF - Current Drug Delivery

IS - 1

ER -

Rodríguez-Félix DE, Castillo-Ortega MM, Nájera-Luna AL, Montaño-Figueroa AG, López-Peña IY, Del Castillo-Castro T et al. Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin. Current Drug Delivery. 2016 Feb 1;13(1):49-56. doi: 10.2174/1567201813666151204121752

Preparation and characterization of coaxial electrospun fibers containing triclosan for comparative study of release properties with amoxicillin and epicatechin

Abstract

Bibliographical note

Keywords

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