Preparation of polyaniline submicro/nanostructures using l-glutamic acid: Loading and releasing studies of amoxicillin. Loading and releasing studies of amoxicillin

C. J. Pérez-Martínez, T. Del Castillo-Castro, M. M. Castillo-Ortega, D. E. Rodríguez-Félix, P. J. Herrera-Franco, V. M. Ovando-Medina, C.J. Perez-Martinez

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Hybrid submicro/nanostructures of polyaniline (PANI) and l-glutamic acid (GA) were chemically prepared with the addition of ammonium persulfate (APS) as the oxidant. Different GA and APS concentrations were investigated in order to obtain the optimal conditions for the formation of high aspect ratio structures. TEM, electrical and XPS characterizations revealed that at monomer:amino acid:oxidant molar ratio of 1:0.25:1, the PANI presented a fibrillar morphology with diameters in submicro and nanometric scale, the structures were coating with the GA and the GA doped the PANI backbone. The fibrillar structures of GA coated-PANI efficiently adsorbed therapeutic doses of amoxicillin and controlled release of the drug can be achieved in function of pH environment, with a maximum cumulative release of 98% at pH 9 within 48 h. © 2013 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalSynthetic Metals
StatePublished - 1 Jan 2013

Bibliographical note

Cited By :7

Export Date: 23 April 2019


Correspondence Address: Del Castillo-Castro, T.; Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, CP 83000 Hermosillo, Sonora, Mexico; email:

Funding details: Consejo Nacional de Ciencia y Tecnología, 2012-N°180280

Funding text 1: This work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico (Grant Ciencia Básica 2012-N°180280 ). The authors thank Roberto Mora for XPS experiments and Silvia Burruel for SEM images. The authors also thank Ramón Íñiguez (Laboratorio de Microscopía Electrónica de Transmisión-UNISON) for TEM images. C.J. Pérez-Martínez acknowledges CONACYT for the scholarship during this study. Appendix A

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  • Amoxicillin
  • Drug controlled release
  • Nanostructures
  • Polyaniline
  • Fibrillar morphology
  • Fibrillar structures
  • High aspect ratio structures
  • Optimal conditions
  • Polyanilines (PAni)
  • XPS characterization
  • Amino acids
  • Drug dosage
  • Oxidants
  • Loading


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