Propuesta de un panel MIRU-VNTR 5 para el tamizaje de aislamientos clínicos de Mycobacterium tuberculosis en México

Translated title of the contribution: Proposal of a five MIRU-VNTR panel to screen clinical isolates of Mycobacterium tuberculosis in Mexico

Enrique Bolado-Martínez*, Maria Del Carmen Candia-Plata, Roberto Zenteno-Cuevas, Fabiola Mendoza Damián, Magali Avilés-Acosta, Gerardo Álvarez-Hernández

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction Tuberculosis is a public health problem across Mexico. This paper aims to select a panel, with a minimum number of repetitive elements (MIRU-VNTR) for genotypic characterization of Mycobacterium tuberculosis (M. tuberculosis) clinical isolates. Method In this study, a full panel of 24 MIRU-VNTR loci was used to discriminate 65 clinical isolates of M. tuberculosis from three different geographical regions of Mexico. Those loci with the highest discriminatory power were subsequently selected. Results The panel, including five loci, was obtained by selecting the highest values of allelic diversity among the genotypes obtained. The dendrogram, generated by the panel MIRU-VNTR 5, showed a high discriminatory power with 65 unique genotype profiles and formed clusters according to the geographical region of origin. Conclusions The panel MIRU-VNTR 5 can be useful for characterizing clinical isolates of M. tuberculosis in Mexico.

Translated title of the contributionProposal of a five MIRU-VNTR panel to screen clinical isolates of Mycobacterium tuberculosis in Mexico
Original languageSpanish
Pages (from-to)609-612
Number of pages4
JournalEnfermedades Infecciosas y Microbiologia Clinica
Volume33
Issue number9
DOIs
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica.

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