Reviewing the Potential of Natural Antimicrobials for Salmonella spp. Gastrointestinal Infections: In Vitro and In Vivo Evaluations

Ildefonso Guerrero-Encinas, Javier N. González-González, Jesús F. Ayala-Zavala, Gustavo A. González-Aguilar, Ana I. Ledesma-Osuna, Marco A. López-Mata, Gloria G. Morales-Figueroa, Luis Quihui-Cota*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Gastrointestinal infections caused by some Salmonella species pose a significant public health challenge. These bacteria can be transmitted through contaminated food and drinks, resulting in health complications. The Salmonella genus is responsible for approximately 16 million cases of gastrointestinal diseases worldwide each year. Although antibiotics are the primary treatment for these infections, their inappropriate use has led to the emergence of antibiotic-resistant bacteria. This represents a threat to the control of these pathogens, emphasizing the importance of exploring alternatives to manage and mitigate this issue. Plant extracts have been regarded as a potential alternative for treating salmonellosis, like Heteromorpha arborescens, Hypericum roeperianum, and Cremaspora triflora in vitro, and Urtica urens in vivo, showing their antimicrobial effectiveness. Further research is needed to understand their mechanisms of action, safety for epithelial tissues, and effective dosages in relation to cytotoxicity. These investigations are a current challenge in developing alternatives for salmonellosis treatment. Therefore, this review aims to discuss the documented uses of plant extracts to fight Salmonella infections. Graphical Abstract: (Figure presented.)

Original languageEnglish
Pages (from-to)236-249
Number of pages14
JournalRevista Brasileira de Farmacognosia
Issue number2
StatePublished - Apr 2024

Bibliographical note

Publisher Copyright:
© The Author(s) under exclusive licence to Sociedade Brasileira de Farmacognosia 2023.


  • Antibiotics
  • Foodborne pathogen
  • Gastrointestinal infections
  • Health
  • Natural perspectives


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