Risk factors for chronic kidney disease of non-traditional causes

a systematic review

Evelina Chapman, Michelle M Haby, Eduardo Illanes, Julian Sanchez-Viamonte, Vanessa Elias, Ludovic Reveiz

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Objectives: To evaluate the potential associations between chronic kidney disease of uncertain or non-traditional etiology (CKDnT) and agrochemicals, heat stress, heavy metals, and other factors identified in the literature in any region of the world and at any time.

Methods: This was a systematic review of the most frequent exposures suspected to be possible causes of CKDnT. A search was conducted of PubMed, LILACS, World Wide Science electronic databases, among other sources. Only medium- and high-quality studies were included. The synthesis of evidence included a narrative synthesis, meta-analysis, and meta-regression.

Results: Four systematic reviews and 61 primary studies were included. Results of the meta-analysis suggest that exposure to agrochemicals and working in agriculture increase the risk of CKDnT, but this only reached significance for working in agriculture. When cross-sectional studies were excluded, agrochemical exposure became significant. However, there is substantial heterogeneity in the effect sizes.

Conclusions: Based on the existing evidence and the precautionary principle, it is important to implement preventive measures to mitigate the damage caused by CKDnT to both agricultural workers and their communities (i.e., improvement of working conditions, cautious management of agrochemicals, etc.). More high-quality research is needed to measure impact and to build the evidence base.

Original languageEnglish
Pages (from-to)e35
JournalRevista Panamericana de Salud Publica/Pan American Journal of Public Health
Volume43
DOIs
StatePublished - 2019
Externally publishedYes

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Agrochemicals
Chronic Renal Insufficiency
Agriculture
Meta-Analysis
Heavy Metals
PubMed
Cross-Sectional Studies
Hot Temperature
Databases
Research

Cite this

Chapman, Evelina ; Haby, Michelle M ; Illanes, Eduardo ; Sanchez-Viamonte, Julian ; Elias, Vanessa ; Reveiz, Ludovic. / Risk factors for chronic kidney disease of non-traditional causes : a systematic review. In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 2019 ; Vol. 43. pp. e35.
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abstract = "Objectives: To evaluate the potential associations between chronic kidney disease of uncertain or non-traditional etiology (CKDnT) and agrochemicals, heat stress, heavy metals, and other factors identified in the literature in any region of the world and at any time.Methods: This was a systematic review of the most frequent exposures suspected to be possible causes of CKDnT. A search was conducted of PubMed, LILACS, World Wide Science electronic databases, among other sources. Only medium- and high-quality studies were included. The synthesis of evidence included a narrative synthesis, meta-analysis, and meta-regression.Results: Four systematic reviews and 61 primary studies were included. Results of the meta-analysis suggest that exposure to agrochemicals and working in agriculture increase the risk of CKDnT, but this only reached significance for working in agriculture. When cross-sectional studies were excluded, agrochemical exposure became significant. However, there is substantial heterogeneity in the effect sizes.Conclusions: Based on the existing evidence and the precautionary principle, it is important to implement preventive measures to mitigate the damage caused by CKDnT to both agricultural workers and their communities (i.e., improvement of working conditions, cautious management of agrochemicals, etc.). More high-quality research is needed to measure impact and to build the evidence base.",
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Risk factors for chronic kidney disease of non-traditional causes : a systematic review. / Chapman, Evelina; Haby, Michelle M; Illanes, Eduardo; Sanchez-Viamonte, Julian; Elias, Vanessa; Reveiz, Ludovic.

In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health, Vol. 43, 2019, p. e35.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Risk factors for chronic kidney disease of non-traditional causes

T2 - a systematic review

AU - Chapman, Evelina

AU - Haby, Michelle M

AU - Illanes, Eduardo

AU - Sanchez-Viamonte, Julian

AU - Elias, Vanessa

AU - Reveiz, Ludovic

PY - 2019

Y1 - 2019

N2 - Objectives: To evaluate the potential associations between chronic kidney disease of uncertain or non-traditional etiology (CKDnT) and agrochemicals, heat stress, heavy metals, and other factors identified in the literature in any region of the world and at any time.Methods: This was a systematic review of the most frequent exposures suspected to be possible causes of CKDnT. A search was conducted of PubMed, LILACS, World Wide Science electronic databases, among other sources. Only medium- and high-quality studies were included. The synthesis of evidence included a narrative synthesis, meta-analysis, and meta-regression.Results: Four systematic reviews and 61 primary studies were included. Results of the meta-analysis suggest that exposure to agrochemicals and working in agriculture increase the risk of CKDnT, but this only reached significance for working in agriculture. When cross-sectional studies were excluded, agrochemical exposure became significant. However, there is substantial heterogeneity in the effect sizes.Conclusions: Based on the existing evidence and the precautionary principle, it is important to implement preventive measures to mitigate the damage caused by CKDnT to both agricultural workers and their communities (i.e., improvement of working conditions, cautious management of agrochemicals, etc.). More high-quality research is needed to measure impact and to build the evidence base.

AB - Objectives: To evaluate the potential associations between chronic kidney disease of uncertain or non-traditional etiology (CKDnT) and agrochemicals, heat stress, heavy metals, and other factors identified in the literature in any region of the world and at any time.Methods: This was a systematic review of the most frequent exposures suspected to be possible causes of CKDnT. A search was conducted of PubMed, LILACS, World Wide Science electronic databases, among other sources. Only medium- and high-quality studies were included. The synthesis of evidence included a narrative synthesis, meta-analysis, and meta-regression.Results: Four systematic reviews and 61 primary studies were included. Results of the meta-analysis suggest that exposure to agrochemicals and working in agriculture increase the risk of CKDnT, but this only reached significance for working in agriculture. When cross-sectional studies were excluded, agrochemical exposure became significant. However, there is substantial heterogeneity in the effect sizes.Conclusions: Based on the existing evidence and the precautionary principle, it is important to implement preventive measures to mitigate the damage caused by CKDnT to both agricultural workers and their communities (i.e., improvement of working conditions, cautious management of agrochemicals, etc.). More high-quality research is needed to measure impact and to build the evidence base.

U2 - 10.26633/RPSP.2019.35

DO - 10.26633/RPSP.2019.35

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JO - Revista Panamericana de Salud Publica/Pan American Journal of Public Health

JF - Revista Panamericana de Salud Publica/Pan American Journal of Public Health

SN - 1020-4989

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