Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam)

G. Ruiz-Montañez; A. Burgos-Hernández; M. Calderón-Santoyo; C. M. López-Saiz; C. A. Velázquez-Contreras; A. Navarro-Ocaña; J. A. Ragazzo-Sánchez

doi:10.1016/j.foodchem.2014.11.122

Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam)

G. Ruiz-Montañez, A. Burgos-Hernández, M. Calderón-Santoyo^*, C. M. López-Saiz, C. A. Velázquez-Contreras, A. Navarro-Ocaña, J. A. Ragazzo-Sánchez

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jackfruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line.

Original language	English
Pages (from-to)	409-416
Number of pages	8
Journal	Food Chemistry
Volume	175
DOIs	https://doi.org/10.1016/j.foodchem.2014.11.122
State	Published - 15 May 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd.

Keywords

Antimutagenic
Antioxidant
Antiproliferative
Chemoprotective properties
Jackfruit pulp
RP-HPLC

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10.1016/j.foodchem.2014.11.122

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Ruiz-Montañez, G., Burgos-Hernández, A., Calderón-Santoyo, M., López-Saiz, C. M., Velázquez-Contreras, C. A., Navarro-Ocaña, A., & Ragazzo-Sánchez, J. A. (2015). Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam). Food Chemistry, 175, 409-416. https://doi.org/10.1016/j.foodchem.2014.11.122

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abstract = "The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jackfruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line.",

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Ruiz-Montañez, G, Burgos-Hernández, A, Calderón-Santoyo, M, López-Saiz, CM , Velázquez-Contreras, CA, Navarro-Ocaña, A & Ragazzo-Sánchez, JA 2015, 'Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam)', Food Chemistry, vol. 175, pp. 409-416. https://doi.org/10.1016/j.foodchem.2014.11.122

TY - JOUR

T1 - Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam)

AU - Ruiz-Montañez, G.

AU - Burgos-Hernández, A.

AU - Calderón-Santoyo, M.

AU - López-Saiz, C. M.

AU - Velázquez-Contreras, C. A.

AU - Navarro-Ocaña, A.

AU - Ragazzo-Sánchez, J. A.

PY - 2015/5/15

Y1 - 2015/5/15

N2 - The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jackfruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line.

AB - The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jackfruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line.

KW - Antimutagenic

KW - Antioxidant

KW - Antiproliferative

KW - Chemoprotective properties

KW - Jackfruit pulp

KW - RP-HPLC

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U2 - 10.1016/j.foodchem.2014.11.122

DO - 10.1016/j.foodchem.2014.11.122

M3 - Artículo

SN - 0308-8146

VL - 175

SP - 409

EP - 416

JO - Food Chemistry

JF - Food Chemistry

ER -

Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam)

Abstract

Bibliographical note

Keywords

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