Seroepidemiology of Toxoplasma gondii Infection in Women of Reproductive Age

A Cross-Sectional Study in a Northwestern Mexican City

Cosme Alvarado-Esquivel, Maria Alba Guadalupe Corella-Madueno, Jesus Hernandez-Tinoco, Antonio Rascon-Careaga, Luis Francisco Sanchez-Anguiano, Karla Guadalupe Martinez-Robinson, Maria Lourdes Aldana-Madrid, Trinidad Quizan-Plata, Maria Guadalupe Canez-Carrasco, Cinthia Jhovanna Perez-Martinez

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Through a cross-sectional survey, we determined the seroprevalence and correlates of Toxoplasma gondii (T. gondii) infection in women of reproductive age in Hermosillo City, Mexico.

Methods: We studied 445 women of reproductive age in Hermosillo City in the northwestern Mexican state of Sonora. Women were enrolled in the University of Sonora. Sera of women were examined for IgG and IgM antibodies to T. gondii by commercially available enzyme immunoassays. The association of T. gondii seropositivity with the characteristics of the pregnant women was determined by bivariate and multivariate analyses.

Results: Of the 445 women (mean age: 22.18 ± 5.6 years) studied, 16 (3.6%) had IgG antibodies to T. gondii, and two (12.5%) were also positive for IgM antibodies to T. gondii. Of the 16 anti-T. gondii IgG-positive women, six (37.5%) had IgG levels higher than 150 IU/mL, four (25.0%) between 100 and 150 IU/mL, and six (37.5%) between 9 and 99 IU/mL. Multivariate analysis of socio-demographic and behavioral variables showed that T. gondii seropositivity was associated with older age (odds ratio (OR): 5.30; 95% confidence interval (CI): 1.37 - 20.50; P = 0.01) and boar meat consumption (OR: 6.86; 95% CI: 1.27 - 37.07; P = 0.02).

Conclusions: Women of reproductive age in Hermosillo City had a low seroprevalence of T. gondii infection. However, this finding indicates that most of these women were susceptible to a primary infection. Factors associated with T. gondii infection found in this study may be useful for the optimal planning of preventive measures against T. gondii infection and its sequelae.

Original languageEnglish
Pages (from-to)210-216
Number of pages7
JournalJournal of Clinical Medicine Research
Volume10
Issue number3
DOIs
StatePublished - Mar 2018

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Toxoplasmosis
Toxoplasma
Cross-Sectional Studies
Immunoglobulin G
Seroepidemiologic Studies
Immunoglobulin M
Antibodies
Multivariate Analysis
Odds Ratio
Confidence Intervals
Mexico
Immunoenzyme Techniques
Meat
Pregnant Women
Demography
Infection
Serum

Cite this

Alvarado-Esquivel, Cosme ; Corella-Madueno, Maria Alba Guadalupe ; Hernandez-Tinoco, Jesus ; Rascon-Careaga, Antonio ; Sanchez-Anguiano, Luis Francisco ; Martinez-Robinson, Karla Guadalupe ; Aldana-Madrid, Maria Lourdes ; Quizan-Plata, Trinidad ; Canez-Carrasco, Maria Guadalupe ; Perez-Martinez, Cinthia Jhovanna. / Seroepidemiology of Toxoplasma gondii Infection in Women of Reproductive Age : A Cross-Sectional Study in a Northwestern Mexican City. In: Journal of Clinical Medicine Research. 2018 ; Vol. 10, No. 3. pp. 210-216.
@article{816c7350ef034e99a7b22cbab4a8ca35,
title = "Seroepidemiology of Toxoplasma gondii Infection in Women of Reproductive Age: A Cross-Sectional Study in a Northwestern Mexican City",
abstract = "Background: Through a cross-sectional survey, we determined the seroprevalence and correlates of Toxoplasma gondii (T. gondii) infection in women of reproductive age in Hermosillo City, Mexico.Methods: We studied 445 women of reproductive age in Hermosillo City in the northwestern Mexican state of Sonora. Women were enrolled in the University of Sonora. Sera of women were examined for IgG and IgM antibodies to T. gondii by commercially available enzyme immunoassays. The association of T. gondii seropositivity with the characteristics of the pregnant women was determined by bivariate and multivariate analyses.Results: Of the 445 women (mean age: 22.18 ± 5.6 years) studied, 16 (3.6{\%}) had IgG antibodies to T. gondii, and two (12.5{\%}) were also positive for IgM antibodies to T. gondii. Of the 16 anti-T. gondii IgG-positive women, six (37.5{\%}) had IgG levels higher than 150 IU/mL, four (25.0{\%}) between 100 and 150 IU/mL, and six (37.5{\%}) between 9 and 99 IU/mL. Multivariate analysis of socio-demographic and behavioral variables showed that T. gondii seropositivity was associated with older age (odds ratio (OR): 5.30; 95{\%} confidence interval (CI): 1.37 - 20.50; P = 0.01) and boar meat consumption (OR: 6.86; 95{\%} CI: 1.27 - 37.07; P = 0.02).Conclusions: Women of reproductive age in Hermosillo City had a low seroprevalence of T. gondii infection. However, this finding indicates that most of these women were susceptible to a primary infection. Factors associated with T. gondii infection found in this study may be useful for the optimal planning of preventive measures against T. gondii infection and its sequelae.",
author = "Cosme Alvarado-Esquivel and Corella-Madueno, {Maria Alba Guadalupe} and Jesus Hernandez-Tinoco and Antonio Rascon-Careaga and Sanchez-Anguiano, {Luis Francisco} and Martinez-Robinson, {Karla Guadalupe} and Aldana-Madrid, {Maria Lourdes} and Trinidad Quizan-Plata and Canez-Carrasco, {Maria Guadalupe} and Perez-Martinez, {Cinthia Jhovanna}",
year = "2018",
month = "3",
doi = "10.14740/jocmr3284w",
language = "Ingl{\'e}s",
volume = "10",
pages = "210--216",
journal = "Journal of Clinical Medicine Research",
issn = "1918-3011",
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Alvarado-Esquivel, C, Corella-Madueno, MAG, Hernandez-Tinoco, J, Rascon-Careaga, A, Sanchez-Anguiano, LF, Martinez-Robinson, KG, Aldana-Madrid, ML, Quizan-Plata, T, Canez-Carrasco, MG & Perez-Martinez, CJ 2018, 'Seroepidemiology of Toxoplasma gondii Infection in Women of Reproductive Age: A Cross-Sectional Study in a Northwestern Mexican City', Journal of Clinical Medicine Research, vol. 10, no. 3, pp. 210-216. https://doi.org/10.14740/jocmr3284w

Seroepidemiology of Toxoplasma gondii Infection in Women of Reproductive Age : A Cross-Sectional Study in a Northwestern Mexican City. / Alvarado-Esquivel, Cosme; Corella-Madueno, Maria Alba Guadalupe; Hernandez-Tinoco, Jesus; Rascon-Careaga, Antonio; Sanchez-Anguiano, Luis Francisco; Martinez-Robinson, Karla Guadalupe; Aldana-Madrid, Maria Lourdes; Quizan-Plata, Trinidad; Canez-Carrasco, Maria Guadalupe; Perez-Martinez, Cinthia Jhovanna.

In: Journal of Clinical Medicine Research, Vol. 10, No. 3, 03.2018, p. 210-216.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Seroepidemiology of Toxoplasma gondii Infection in Women of Reproductive Age

T2 - A Cross-Sectional Study in a Northwestern Mexican City

AU - Alvarado-Esquivel, Cosme

AU - Corella-Madueno, Maria Alba Guadalupe

AU - Hernandez-Tinoco, Jesus

AU - Rascon-Careaga, Antonio

AU - Sanchez-Anguiano, Luis Francisco

AU - Martinez-Robinson, Karla Guadalupe

AU - Aldana-Madrid, Maria Lourdes

AU - Quizan-Plata, Trinidad

AU - Canez-Carrasco, Maria Guadalupe

AU - Perez-Martinez, Cinthia Jhovanna

PY - 2018/3

Y1 - 2018/3

N2 - Background: Through a cross-sectional survey, we determined the seroprevalence and correlates of Toxoplasma gondii (T. gondii) infection in women of reproductive age in Hermosillo City, Mexico.Methods: We studied 445 women of reproductive age in Hermosillo City in the northwestern Mexican state of Sonora. Women were enrolled in the University of Sonora. Sera of women were examined for IgG and IgM antibodies to T. gondii by commercially available enzyme immunoassays. The association of T. gondii seropositivity with the characteristics of the pregnant women was determined by bivariate and multivariate analyses.Results: Of the 445 women (mean age: 22.18 ± 5.6 years) studied, 16 (3.6%) had IgG antibodies to T. gondii, and two (12.5%) were also positive for IgM antibodies to T. gondii. Of the 16 anti-T. gondii IgG-positive women, six (37.5%) had IgG levels higher than 150 IU/mL, four (25.0%) between 100 and 150 IU/mL, and six (37.5%) between 9 and 99 IU/mL. Multivariate analysis of socio-demographic and behavioral variables showed that T. gondii seropositivity was associated with older age (odds ratio (OR): 5.30; 95% confidence interval (CI): 1.37 - 20.50; P = 0.01) and boar meat consumption (OR: 6.86; 95% CI: 1.27 - 37.07; P = 0.02).Conclusions: Women of reproductive age in Hermosillo City had a low seroprevalence of T. gondii infection. However, this finding indicates that most of these women were susceptible to a primary infection. Factors associated with T. gondii infection found in this study may be useful for the optimal planning of preventive measures against T. gondii infection and its sequelae.

AB - Background: Through a cross-sectional survey, we determined the seroprevalence and correlates of Toxoplasma gondii (T. gondii) infection in women of reproductive age in Hermosillo City, Mexico.Methods: We studied 445 women of reproductive age in Hermosillo City in the northwestern Mexican state of Sonora. Women were enrolled in the University of Sonora. Sera of women were examined for IgG and IgM antibodies to T. gondii by commercially available enzyme immunoassays. The association of T. gondii seropositivity with the characteristics of the pregnant women was determined by bivariate and multivariate analyses.Results: Of the 445 women (mean age: 22.18 ± 5.6 years) studied, 16 (3.6%) had IgG antibodies to T. gondii, and two (12.5%) were also positive for IgM antibodies to T. gondii. Of the 16 anti-T. gondii IgG-positive women, six (37.5%) had IgG levels higher than 150 IU/mL, four (25.0%) between 100 and 150 IU/mL, and six (37.5%) between 9 and 99 IU/mL. Multivariate analysis of socio-demographic and behavioral variables showed that T. gondii seropositivity was associated with older age (odds ratio (OR): 5.30; 95% confidence interval (CI): 1.37 - 20.50; P = 0.01) and boar meat consumption (OR: 6.86; 95% CI: 1.27 - 37.07; P = 0.02).Conclusions: Women of reproductive age in Hermosillo City had a low seroprevalence of T. gondii infection. However, this finding indicates that most of these women were susceptible to a primary infection. Factors associated with T. gondii infection found in this study may be useful for the optimal planning of preventive measures against T. gondii infection and its sequelae.

U2 - 10.14740/jocmr3284w

DO - 10.14740/jocmr3284w

M3 - Artículo

VL - 10

SP - 210

EP - 216

JO - Journal of Clinical Medicine Research

JF - Journal of Clinical Medicine Research

SN - 1918-3011

IS - 3

ER -