Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum

Alejandro Urrea-Quezada; Ruben Balmaceda-Baca; Adriana Garibay; Jesús Hernández; Olivia Valenzuela

doi:10.3389/fcimb.2021.810887

Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum

Alejandro Urrea-Quezada, Ruben Balmaceda-Baca, Adriana Garibay, Jesús Hernández, Olivia Valenzuela^*

^*Corresponding author for this work

Departamento de Ciencias Químico-Biológicas

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.

Original language	English
Article number	810887
Journal	Frontiers in Cellular and Infection Microbiology
Volume	11
DOIs	https://doi.org/10.3389/fcimb.2021.810887
State	Published - 19 Jan 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Urrea-Quezada, Balmaceda-Baca, Garibay, Hernández and Valenzuela.

Keywords

IgG
emerging parasites
human cryptosporidiosis
humoral response
synthetic peptides

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10.3389/fcimb.2021.810887

Cite this

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title = "Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum",

abstract = "Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.",

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T1 - Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum

AU - Urrea-Quezada, Alejandro

AU - Balmaceda-Baca, Ruben

AU - Garibay, Adriana

AU - Hernández, Jesús

AU - Valenzuela, Olivia

PY - 2022/1/19

Y1 - 2022/1/19

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AB - Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.

KW - IgG

KW - emerging parasites

KW - human cryptosporidiosis

KW - humoral response

KW - synthetic peptides

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JO - Frontiers in Cellular and Infection Microbiology

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Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum

Abstract

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Keywords

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