Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.
Bibliographical noteFunding Information:
This work was supported by the Consejo Nacional de Ciencia y Tecnologıá (CONACyT), Fondo Sectorial de Investigación para la Educación (grant number 258454).
Copyright © 2022 Urrea-Quezada, Balmaceda-Baca, Garibay, Hernández and Valenzuela.
- emerging parasites
- human cryptosporidiosis
- humoral response
- synthetic peptides