Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum

Alejandro Urrea-Quezada, Ruben Balmaceda-Baca, Adriana Garibay, Jesús Hernández, Olivia Valenzuela*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cryptosporidium spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the Cryptosporidium parvum gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with Cryptosporidium hominis, C. parvum, and Cryptosporidium canis, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.

Original languageEnglish
Article number810887
JournalFrontiers in Cellular and Infection Microbiology
Volume11
DOIs
StatePublished - 19 Jan 2022

Bibliographical note

Funding Information:
This work was supported by the Consejo Nacional de Ciencia y Tecnologıá (CONACyT), Fondo Sectorial de Investigación para la Educación (grant number 258454).

Publisher Copyright:
Copyright © 2022 Urrea-Quezada, Balmaceda-Baca, Garibay, Hernández and Valenzuela.

Keywords

  • IgG
  • emerging parasites
  • human cryptosporidiosis
  • humoral response
  • synthetic peptides

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