Shapes of mixed phospholipid vesicles

Gerardo Paredes-Quijada; Helim Aranda-Espinoza; Amir Maldonado

doi:10.1007/s10867-006-9007-y

Shapes of mixed phospholipid vesicles

Gerardo Paredes-Quijada^*, Helim Aranda-Espinoza, Amir Maldonado

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We studied the shape of phospholipid vesicles prepared by hydration of a mixture of phosphatidylcholine (SOPC) and phosphatidylserine (SOPS) in different proportions. The aim of the work is to obtain some insight into the influence of the chemical composition of a biomembrane on its shape. The optical microscopy results show that the shape of the vesicles depend on the SOPC:SOPS composition. For low SOPS contents, coiled cylindrical vesicles are observed. The results suggest that specific compositions of the SOPC:SOPS vesicles produce some spontaneous curvature on the membrane and then a coiling instability.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Journal of Biological Physics
Volume	32
Issue number	2
DOIs	https://doi.org/10.1007/s10867-006-9007-y
State	Published - Oct 2006

Bibliographical note

Funding Information:
G. P.-Q. acknowledges a fellowship from Conacyt-Mexico. A. M. acknowledges financial support from Conacyt-Mexico (grants 32105E and 0074) and ANUIES-ECOS (MOOP03). H. A.-E. and G. P.-Q. thank Dennis Discher for allowing us to use his laboratory where initial experiments were done.

Keywords

Biological membranes
Phospholipids
Vesicle coiling
Vesicles

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10.1007/s10867-006-9007-y

Cite this

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title = "Shapes of mixed phospholipid vesicles",

abstract = "We studied the shape of phospholipid vesicles prepared by hydration of a mixture of phosphatidylcholine (SOPC) and phosphatidylserine (SOPS) in different proportions. The aim of the work is to obtain some insight into the influence of the chemical composition of a biomembrane on its shape. The optical microscopy results show that the shape of the vesicles depend on the SOPC:SOPS composition. For low SOPS contents, coiled cylindrical vesicles are observed. The results suggest that specific compositions of the SOPC:SOPS vesicles produce some spontaneous curvature on the membrane and then a coiling instability.",

keywords = "Biological membranes, Phospholipids, Vesicle coiling, Vesicles",

author = "Gerardo Paredes-Quijada and Helim Aranda-Espinoza and Amir Maldonado",

note = "Funding Information: G. P.-Q. acknowledges a fellowship from Conacyt-Mexico. A. M. acknowledges financial support from Conacyt-Mexico (grants 32105E and 0074) and ANUIES-ECOS (MOOP03). H. A.-E. and G. P.-Q. thank Dennis Discher for allowing us to use his laboratory where initial experiments were done.",

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AU - Paredes-Quijada, Gerardo

AU - Aranda-Espinoza, Helim

AU - Maldonado, Amir

N1 - Funding Information: G. P.-Q. acknowledges a fellowship from Conacyt-Mexico. A. M. acknowledges financial support from Conacyt-Mexico (grants 32105E and 0074) and ANUIES-ECOS (MOOP03). H. A.-E. and G. P.-Q. thank Dennis Discher for allowing us to use his laboratory where initial experiments were done.

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N2 - We studied the shape of phospholipid vesicles prepared by hydration of a mixture of phosphatidylcholine (SOPC) and phosphatidylserine (SOPS) in different proportions. The aim of the work is to obtain some insight into the influence of the chemical composition of a biomembrane on its shape. The optical microscopy results show that the shape of the vesicles depend on the SOPC:SOPS composition. For low SOPS contents, coiled cylindrical vesicles are observed. The results suggest that specific compositions of the SOPC:SOPS vesicles produce some spontaneous curvature on the membrane and then a coiling instability.

AB - We studied the shape of phospholipid vesicles prepared by hydration of a mixture of phosphatidylcholine (SOPC) and phosphatidylserine (SOPS) in different proportions. The aim of the work is to obtain some insight into the influence of the chemical composition of a biomembrane on its shape. The optical microscopy results show that the shape of the vesicles depend on the SOPC:SOPS composition. For low SOPS contents, coiled cylindrical vesicles are observed. The results suggest that specific compositions of the SOPC:SOPS vesicles produce some spontaneous curvature on the membrane and then a coiling instability.

KW - Biological membranes

KW - Phospholipids

KW - Vesicle coiling

KW - Vesicles

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U2 - 10.1007/s10867-006-9007-y

DO - 10.1007/s10867-006-9007-y

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VL - 32

SP - 177

EP - 181

JO - Journal of Biological Physics

JF - Journal of Biological Physics

IS - 2

ER -

Shapes of mixed phospholipid vesicles

Abstract

Bibliographical note

Keywords

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