Suplementación con salvado de sorgo mejora la dislipidemia, desregulación de glucosa, inflamación y estrés oxidativo inducidos por una dieta alta en grasa en ratas

Translated title of the contribution: Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats

Norma Julieta Salazar-López, Gustavo A. González-Aguilar, Ofelia Rouzaud-Sández, Guadalupe Loarca-Piña, Shela Gorinstein, Maribel Robles-Sánchez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal diet (BD), which were supplemented with either lard at 310 g/kg (HFD) or lard and ESB at 180 g/kg (HFD + ESB) or lard and RSB (HFD + RSB), for 8 weeks. The intake of HFD supplemented with ESB or RSB hindered the fat storage in adipocytes of abdominal tissue, dyslipidemia and the loss of glucose homeostasis. A positive correlation between inflammation biomarkers (Interleukin-1β and Interleukin-6) and glucose homeostasis was observed, while a negative correlation between antioxidant capacity (TEAC) and Interleukin-1β and Interleukin-6 was observed. As a conclusion, the ESB or RSB may be intended as part of healthy diets.

Translated title of the contributionSorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats
Original languageSpanish
Pages (from-to)20-30
Number of pages11
JournalCYTA - Journal of Food
Volume18
Issue number1
DOIs
StatePublished - 1 Jan 2020

Bibliographical note

Funding Information:
This work was performed with the support of the PROINNOVA grant [project no. 218169]. Norma Julieta Salazar L?pez received a scholarship from CONACyT (National Research and Technology Council) Mexico. We would like to thank Monica Villegas and Bertha Pacheco for their technical support and Julieta Gutierrez for her assistance on the histological analyses.

Publisher Copyright:
© 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

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