Abstract
Spirotetramat, derived from tetramic acid, and commercially known as Movento®, is applied in grapevine orchards and other vegetable for the control of sucking pests. Published in vivo toxicological studies report only a general description of its metabolism. The objective of this study was to detect changes in the behavior, in blood biochemical markers, and in histological liver cells on male Wistar rats treated with spirotetramat. The following treatments were applied: a) acute poisoning with spirotetramat (BY108330, 15.3%) oral route with 1/4 DL (625 mg kg- 50 1) and 1/2 DL (1250 mg kg-1), and b) control. Blood samples were 50 obtained by heart punction on days 1, 3 and 7; the samples were evaluated for changes of biochemical indicators (triglycerides, cholesterol, albumin, total protein, transaminase activity, urea and creatinine), and by histological changes in liver, kidney and pancreas. Death occurred in 35% of the treated animals. Some signs of toxicity were observed: nasal running, diarrhea, salivation, ataxia, convulsions, and bleeding. The average body weight and the liver relative weight were stable during the experiment, without differences between treatments, nor between days. The lipid profile and transaminases showed a clear tendency to increase in relation to the control. In the histological evaluation the hepatocytes showed balloonoide degeneration in 25% (8 of 32) and cholestasis in 72% (23 of 32) of the exposed rats; however, there were not visible changes in spleen and kidney in relation to the control.
| Translated title of the contribution | Spirotetramat induce cambios histológicos y bioquímicos en rata wistar |
|---|---|
| Original language | English |
| Pages (from-to) | 215-217 |
| Number of pages | 3 |
| Journal | Revista de Toxicologia |
| Volume | 30 |
| Issue number | 2 |
| State | Published - 2013 |
Keywords
- By108330
- Insecticides
- Movento
- Spirotetramat
- Toxicological evaluation