Stevens-Johnson syndrome and toxic epidermal necrolysis in children

Norberto Sotelo-Cruz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The Stevens-Johnson syndrome (SJS) and the toxic epidermal necrolysis (TEN) are clinical conditions manifesting as adverse cutaneous reaction to drugs in majority of cases, constituting the same clinical spectrum, differing only in the severity of epidermolysis; both conditions are distinguished by their severity and extensiveness of skin lesions; it can also involve mucous membranes of eyes, respiratory, digestive and urogenital tracts. Two per 1,000,000 are affected annually, among them approximately 20% are children and both of them are considered as potentially fatal medical emergency conditions. Even though the condition was described 89 years ago, until now the exact pathophysiology has not been completely explained. An immune-mediated mechanism has been implicated in its origin, which involves cytotoxic lymphocytes, cytokines, Fas-ligand in keratinocyte apoptosis; genetic makers also has been identified in some racial groups (HLA-B*1520, HLA-B*5801) in relationship with specific susceptibility to certain drugs such as carbamazepine, allopurinol. In children there are no uniform criteria for classification of the skin lesions, neither for the treatment, however recently the authors describe better response of the patients with use intravenous immunoglobulin (IGIV).

Translated title of the contributionSíndrome de Stevens-Johnson y necrólisis epidérmica tóxica en los niños
Original languageEnglish
Pages (from-to)265-275
Number of pages11
JournalGaceta Medica de Mexico
Issue number3
StatePublished - May 2012
Externally publishedYes


  • Intravenous immunoglobulin
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis


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