Sub-chronic consumption of a phenolic-rich avocado paste extract induces GLP-1-, leptin-, and adiponectin-mediated satiety in Wistar rats

Diana A. Corella-Salazar, J. Abraham Domínguez-Avila*, Marcelino Montiel-Herrera, Humberto Astiazaran-Garcia, Norma J. Salazar-López, Mitsuky Soraya Serafín-García, Guadalupe Isela Olivas-Orozco, Francisco Javier Molina-Corral, Gustavo A. González-Aguilar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Avocado paste (AP) is a phenolic-rich byproduct of avocado oil extraction. The effects of sub-chronic consumption of diets supplemented with an AP phenolic extract (PE) were analyzed. A standard diet (SD), high-fat diet (HFD), and these supplemented with PE (SD + PE and HFD + PE) were used. Significantly increased satiety was observed in PE-supplemented groups, according to less food consumption (−15% in SD + PE vs. SD, and −11% in HFD + PE vs. HFD), without changes in weight gain or percentage of adipose tissue. PE-supplemented groups had an increased plasma concentration (+ 16% in SD + PE vs. SD, and +26% in HFD + PE vs. HFD) and relative mRNA expression (+74% in SD + PE vs. SD, and +46% in HFD + PE vs. HFD) of GLP-1; an increase in plasma leptin and adiponectin was independent of their mRNA expression. Our results suggest that AP-derived PE exerts a satiety effect in vivo, possibly mediated by GLP-1, leptin, and adiponectin. Practical applications: Minimizing food waste is a top priority in most of the world, thus, researchers seek methods to reintroduce industrial fruit and vegetable byproducts into the food processing chain. The present work highlights the potential of avocado byproducts as sources of bioactive phenolic compounds, whose sub-chronic consumption (8 weeks) exerts a satiety action in vivo. Avocado farming is resource-intensive, making it of relevance to producers and processing industries to avoid discarding its byproducts as much as possible.

Original languageEnglish
Article numbere13957
JournalJournal of Food Biochemistry
Volume45
Issue number11
DOIs
StatePublished - Nov 2021

Bibliographical note

Funding Information:
This work was supported by Instituto de Bebidas de la Industria Mexicana de Coca‐Cola through project “Inducción de saciedad y modulación de la digestión intestinal de lípidos ejercidos por los compuestos fenólicos de aguacate Hass” (Premio Nacional en Ciencia y Tecnología de Alimentos 2019), and by Centro de Investigación en Alimentación y Desarrollo A. C. (CIAD).

Funding Information:
This work was supported by Instituto de Bebidas de la Industria Mexicana de Coca-Cola through project ?Inducci?n de saciedad y modulaci?n de la digesti?n intestinal de l?pidos ejercidos por los compuestos fen?licos de aguacate Hass? (Premio Nacional en Ciencia y Tecnolog?a de Alimentos 2019), and by Centro de Investigaci?n en Alimentaci?n y Desarrollo A. C. (CIAD). Diana Corella-Salazar thanks Consejo Nacional de Ciencia y Tecnolog?a (CONACyT) for the scholarship that allowed her to obtain her Master's degree. This work was supported by Instituto de Bebidas de la Industria Mexicana de Coca-Cola through project ?Inducci?n de saciedad y modulaci?n de la digesti?n intestinal de l?pidos ejercidos por los compuestos fen?licos de aguacate Hass? (Premio Nacional en Ciencia y Tecnolog?a de Alimentos 2019), and by Centro de Investigaci?n en Alimentaci?n y Desarrollo A. C. (CIAD).

Publisher Copyright:
© 2021 Wiley Periodicals LLC.

Keywords

  • Persea americana Mill
  • byproducts
  • enteroendocrine hormones
  • phenolic acids

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