TY - JOUR
T1 - 1H NMR of paramagnetic Dy3+ complex with DTPA-amide p-xylylene-cyclophane; possible probing action toward D-histidine and histamine
AU - Elena Navarro, Rosa
AU - Serna-Medina, Octavio
AU - Soberanes, Yedith
AU - Cabellos, José Luis
AU - Inoue, Motomichi
AU - Santacruz, Hisila
AU - Posada-Amarillas, Álvaro
PY - 2020/5/1
Y1 - 2020/5/1
N2 - © 2020 Elsevier Ltd As an effort to search for paramagnetic probing agents toward specific substrates, 1H NMR studies were carried out on the Dy3+ complex of a chelating cyclophane derived from DTPA (diethylenetriaminepentaacetate) and p-xylylenediamine, and the paramagnetic effects were examined on coexisting D-histidine and histamine. The lanthanide metal complex exhibits well-defined paramagnetic shifts of the psuedocontact term, owing to the highly rigid macrocyclic framework. Coexisting histamine and histidine also show sharp NMR peaks with small but significant shifts, in contrast to the spectra in the coexistence of the free metal ion. The metal chelate molecule has a large open space, in which a substrate molecule is captured and exchanged with nearby molecules. Through this exchange process, the spatial paramagnetic effect of the metal chelate extends in a long range so that coexisting substrate molecules can be probed by NMR.
AB - © 2020 Elsevier Ltd As an effort to search for paramagnetic probing agents toward specific substrates, 1H NMR studies were carried out on the Dy3+ complex of a chelating cyclophane derived from DTPA (diethylenetriaminepentaacetate) and p-xylylenediamine, and the paramagnetic effects were examined on coexisting D-histidine and histamine. The lanthanide metal complex exhibits well-defined paramagnetic shifts of the psuedocontact term, owing to the highly rigid macrocyclic framework. Coexisting histamine and histidine also show sharp NMR peaks with small but significant shifts, in contrast to the spectra in the coexistence of the free metal ion. The metal chelate molecule has a large open space, in which a substrate molecule is captured and exchanged with nearby molecules. Through this exchange process, the spatial paramagnetic effect of the metal chelate extends in a long range so that coexisting substrate molecules can be probed by NMR.
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U2 - 10.1016/j.poly.2020.114474
DO - 10.1016/j.poly.2020.114474
M3 - Article
JO - Polyhedron
JF - Polyhedron
SN - 0277-5387
ER -