Suplementación con salvado de sorgo mejora la dislipidemia, desregulación de glucosa, inflamación y estrés oxidativo inducidos por una dieta alta en grasa en ratas

Norma Julieta Salazar-López; Gustavo A. González-Aguilar; Ofelia Rouzaud-Sández; Guadalupe Loarca-Piña; Shela Gorinstein; Maribel Robles-Sánchez

doi:10.1080/19476337.2019.1702105

Suplementación con salvado de sorgo mejora la dislipidemia, desregulación de glucosa, inflamación y estrés oxidativo inducidos por una dieta alta en grasa en ratas

Translated title of the contribution: Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats

Norma Julieta Salazar-López, Gustavo A. González-Aguilar, Ofelia Rouzaud-Sández, Guadalupe Loarca-Piña, Shela Gorinstein, Maribel Robles-Sánchez^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal diet (BD), which were supplemented with either lard at 310 g/kg (HFD) or lard and ESB at 180 g/kg (HFD + ESB) or lard and RSB (HFD + RSB), for 8 weeks. The intake of HFD supplemented with ESB or RSB hindered the fat storage in adipocytes of abdominal tissue, dyslipidemia and the loss of glucose homeostasis. A positive correlation between inflammation biomarkers (Interleukin-1β and Interleukin-6) and glucose homeostasis was observed, while a negative correlation between antioxidant capacity (TEAC) and Interleukin-1β and Interleukin-6 was observed. As a conclusion, the ESB or RSB may be intended as part of healthy diets.

Translated title of the contribution	Sorghum bran supplementation ameliorates dyslipidemia, glucose dysregulation, inflammation and stress oxidative induced by a high-fat diet in rats
Original language	Spanish
Pages (from-to)	20-30
Number of pages	11
Journal	CYTA - Journal of Food
Volume	18
Issue number	1
DOIs	https://doi.org/10.1080/19476337.2019.1702105
State	Published - 1 Jan 2020

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Publisher Copyright:
© 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

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Salazar-López, N. J., González-Aguilar, G. A., Rouzaud-Sández, O., Loarca-Piña, G., Gorinstein, S., & Robles-Sánchez, M. (2020). Suplementación con salvado de sorgo mejora la dislipidemia, desregulación de glucosa, inflamación y estrés oxidativo inducidos por una dieta alta en grasa en ratas. CYTA - Journal of Food, 18(1), 20-30. https://doi.org/10.1080/19476337.2019.1702105

@article{1ec5bb825d764c819a9acabe49a4ba53,

title = "Suplementaci{\'o}n con salvado de sorgo mejora la dislipidemia, desregulaci{\'o}n de glucosa, inflamaci{\'o}n y estr{\'e}s oxidativo inducidos por una dieta alta en grasa en ratas",

abstract = "A study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal diet (BD), which were supplemented with either lard at 310 g/kg (HFD) or lard and ESB at 180 g/kg (HFD + ESB) or lard and RSB (HFD + RSB), for 8 weeks. The intake of HFD supplemented with ESB or RSB hindered the fat storage in adipocytes of abdominal tissue, dyslipidemia and the loss of glucose homeostasis. A positive correlation between inflammation biomarkers (Interleukin-1β and Interleukin-6) and glucose homeostasis was observed, while a negative correlation between antioxidant capacity (TEAC) and Interleukin-1β and Interleukin-6 was observed. As a conclusion, the ESB or RSB may be intended as part of healthy diets.",

keywords = "dyslipidemia, high-fat diet, inflammation, Sorghum bran",

author = "Salazar-L{\'o}pez, {Norma Julieta} and Gonz{\'a}lez-Aguilar, {Gustavo A.} and Ofelia Rouzaud-S{\'a}ndez and Guadalupe Loarca-Pi{\~n}a and Shela Gorinstein and Maribel Robles-S{\'a}nchez",

note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.",

year = "2020",

month = jan,

day = "1",

doi = "10.1080/19476337.2019.1702105",

language = "Espa{\~n}ol",

volume = "18",

pages = "20--30",

journal = "CYTA - Journal of Food",

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Salazar-López, NJ, González-Aguilar, GA, Rouzaud-Sández, O, Loarca-Piña, G, Gorinstein, S & Robles-Sánchez, M 2020, 'Suplementación con salvado de sorgo mejora la dislipidemia, desregulación de glucosa, inflamación y estrés oxidativo inducidos por una dieta alta en grasa en ratas', CYTA - Journal of Food, vol. 18, no. 1, pp. 20-30. https://doi.org/10.1080/19476337.2019.1702105

Suplementación con salvado de sorgo mejora la dislipidemia, desregulación de glucosa, inflamación y estrés oxidativo inducidos por una dieta alta en grasa en ratas. / Salazar-López, Norma Julieta; González-Aguilar, Gustavo A.; Rouzaud-Sández, Ofelia et al.
In: CYTA - Journal of Food, Vol. 18, No. 1, 01.01.2020, p. 20-30.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Suplementación con salvado de sorgo mejora la dislipidemia, desregulación de glucosa, inflamación y estrés oxidativo inducidos por una dieta alta en grasa en ratas

AU - Salazar-López, Norma Julieta

AU - González-Aguilar, Gustavo A.

AU - Rouzaud-Sández, Ofelia

AU - Loarca-Piña, Guadalupe

AU - Gorinstein, Shela

AU - Robles-Sánchez, Maribel

PY - 2020/1/1

Y1 - 2020/1/1

N2 - A study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal diet (BD), which were supplemented with either lard at 310 g/kg (HFD) or lard and ESB at 180 g/kg (HFD + ESB) or lard and RSB (HFD + RSB), for 8 weeks. The intake of HFD supplemented with ESB or RSB hindered the fat storage in adipocytes of abdominal tissue, dyslipidemia and the loss of glucose homeostasis. A positive correlation between inflammation biomarkers (Interleukin-1β and Interleukin-6) and glucose homeostasis was observed, while a negative correlation between antioxidant capacity (TEAC) and Interleukin-1β and Interleukin-6 was observed. As a conclusion, the ESB or RSB may be intended as part of healthy diets.

AB - A study on the effects of extruded sorghum bran (ESB) or raw sorghum bran (RSB) on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Four groups of male Wistar rats (six per group) consumed a basal diet (BD), which were supplemented with either lard at 310 g/kg (HFD) or lard and ESB at 180 g/kg (HFD + ESB) or lard and RSB (HFD + RSB), for 8 weeks. The intake of HFD supplemented with ESB or RSB hindered the fat storage in adipocytes of abdominal tissue, dyslipidemia and the loss of glucose homeostasis. A positive correlation between inflammation biomarkers (Interleukin-1β and Interleukin-6) and glucose homeostasis was observed, while a negative correlation between antioxidant capacity (TEAC) and Interleukin-1β and Interleukin-6 was observed. As a conclusion, the ESB or RSB may be intended as part of healthy diets.

KW - dyslipidemia

KW - high-fat diet

KW - inflammation

KW - Sorghum bran

UR - http://www.scopus.com/inward/record.url?scp=85077068943&partnerID=8YFLogxK

U2 - 10.1080/19476337.2019.1702105

DO - 10.1080/19476337.2019.1702105

M3 - Artículo

AN - SCOPUS:85077068943

SN - 1947-6337

VL - 18

SP - 20

EP - 30

JO - CYTA - Journal of Food

JF - CYTA - Journal of Food

IS - 1

ER -

Suplementación con salvado de sorgo mejora la dislipidemia, desregulación de glucosa, inflamación y estrés oxidativo inducidos por una dieta alta en grasa en ratas

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