One of the main challenges facing materials science today is the synthesis of new biodegradable and biocompatible materials capable of improving existing ones. This work focused on the synthesis of new biomaterials from the bioconjugation of oleic acid with L-cysteine using carbodi-imide. The resulting reaction leads to amide bonds between the carboxylic acid of oleic acid and the primary amine of L-cysteine. The formation of the bioconjugate was corroborated by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and nuclear magnetic resonance (NMR). In these techniques, the development of new materials with marked differences with the precursors was confirmed. Furthermore, NMR has elucidated a surfactant structure, with a hydrophilic part and a hydrophobic section. Ultraviolet-visible spectroscopy (UV-Vis) was used to determine the critical micellar concentration (CMC) of the bioconjugate. Subsequently, light diffraction (DLS) was used to analyze the size of the resulting self-assembled structures. Finally, transmission electron microscopy (TEM) was obtained, where the shape and size of the self-assembled structures were appreciated.
Bibliographical noteFunding Information:
The APC was funded by Consejo Nacional de Ciencia y Tecnolog?a (CONACYT) from Mexico through the National Graduate Scholarship Programs. We acknowledge Susana ?lvarez from the ?Physics Research Department? at the University of Sonora for helping us with the characterizations in the Raman equipment. We are grateful for the use of the transmission electron microscopy (TEM) facilities of the University of Sonora, and we thank Refugio P?rez-Gonz?lez and Ram?n Moreno of the Spectroscopy Laboratory of the Department of Polymers and Materials of the University. Sonora for providing the1 H-NMR spectra.
Funding: The APC was funded by Consejo Nacional de Ciencia y Tecnología (CONACYT) from Mexico through the National Graduate Scholarship Programs.
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- Oleic acid