Synthesis and ITC characterization of novel nanoparticles constituted by poly(γ-benzyl L-glutamate)-β-cyclodextrin

Ma Elisa Martínez Barbosa, Laurent Bouteiller, Sandrine Cammas-Marion, Véronique Montembault, Laurent Fontaine, Gilles Ponchel

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21 Scopus citations


Imparting desired technological characteristics to polymeric nanoparticles requires the development of original polymers. In the present work, the synthesis and characterization of a novel PBLG-derivative, the poly(γ-benzyl L-glutamate)-β-cyclodextrin (PBLG-β-CD-50), have been carried out. Nanoparticles from either PBLG-β-CD-50 polymer or from mixtures with PBLG have been prepared using a modified nanoprecipitation method. Spherically shaped nanoparticles with diameter in the range of 50-70 nm were obtained, as determined by dynamic laser light scattering and transmission electron microscopy. The presence of a surfactant in the suspension medium had almost no influence on these parameters and was not necessary to the shelf-stability of the suspension. Further, isothermal titration microcalorimetry (ITC) experiments have been used to show unambiguously that about 20% of the cyclodextrins remain functional within the particles. Consequently, this system may be of interest when association of large amounts of hydrophobic drugs to nanoparticles is required.

Original languageEnglish
Pages (from-to)169-178
Number of pages10
JournalJournal of Molecular Recognition
Issue number3
StatePublished - 2008


  • ITC
  • Inclusion
  • Multifunctional nanoparticles
  • Nanoprecipitation
  • PBLG nanoparticles
  • Poly(γ-benzyl L-glutamate)-β-cyclodextrin


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