Temperature stimuli-responsive nanoparticles from chitosan-graft-poly(N-vinylcaprolactam) as a drug delivery system: NA

Daniel Fernández-Quiroz*, Jorge Loya-Duarte, Erika Silva-Campa, Waldo Argüelles-Monal, Andre Sarabia-Sainz, Armando Lucero-Acuña, Teresa del Castillo-Castro, Julio San Román, Jaime Lizardi-Mendoza, Alexel J. Burgara-Estrella, Beatriz Castaneda, Diego Soto-Puebla, Martín Pedroza-Montero

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

This work describes the preparation of thermosensitive chitosan-graft-poly(N-vinylcaprolactam) nanoparticles by ionic gelation and their potential use as a controlled drug delivery system, using doxorubicin as a model drug. A systematic study of the effect of the main processing parameters on both the size and thermoresponsive behavior of nanoparticles was investigated. The size of the particles is strongly dependent on the length of the poly(N-vinylcaprolactam) grafted chains and the concentration of the copolymer and crosslinking agent solutions. The molecular structure of the copolymer plays an essential role in the phase transition temperature of the particles, which decreases with the length of PVCL grafted chain. The system displayed proper drug-association parameters, and the drug-loaded nanoparticles exhibited dose-dependent cytotoxicity. A significant increase in the doxorubicin delivery rate was observed above the phase transition temperature (40 °C). These features indicate that these nanoparticles are suitable for the development of a new thermally controlled anti-cancer drug delivery system.

Translated title of the contributionNA: NA
Original languageEnglish
Article number47831
JournalJournal of Applied Polymer Science
Volume136
Issue number32
DOIs
StatePublished - 1 Jan 2019

Bibliographical note

Funding Information:
The authors acknowledge the Mexican Council of Science and Technology (CONACYT) for their financial support through the project PDCAPN-2014/248982. D.F.Q. acknowledges a grant from CON-ACYT (AIIVFPN-2017/291229). The authors are grateful for the technical support of Dr. Álvaro González-Gómez from ICTP-CSIC and M.C. Karla Martínez-Robinson, M.C. Luisa L. Silva, Q.B. Alma Campa-Mada, and Prof. Miguel A. Martínez-Tellez from CIAD.

Funding Information:
The authors acknowledge the Mexican Council of Science and Technology (CONACYT) for their financial support through the project PDCAPN-2014/248982. D.F.Q. acknowledges a grant from CONACYT (AIIVFPN-2017/291229). The authors are grateful for the technical support of Dr. ?lvaro Gonz?lez-G?mez from ICTP-CSIC and M.C. Karla Mart?nez-Robinson, M.C. Luisa L. Silva, Q.B. Alma Campa-Mada, and Prof. Miguel A. Mart?nez-Tellez from CIAD.

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

Keywords

  • biomaterials
  • biomedical applications
  • drug delivery systems
  • nanostructured polymers
  • stimuli-sensitive polymers

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