Two cases of hypergranular acute lymphoblastic leukemia

Enrique Bolado-Martínez, Martha Vivanco-Jiménez, Francisco García-Ramírez, Guillermo Ruiz-Reyes, Alejandro Ruiz-Argüelles, Guillermo J. Ruiz-Argüelles*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Two patients with hypergranular acute lymphoblastic leukemia are presented: they represent 1.4% of patients with acute lymphoblastic leukemia studied and treated in a single institution in the past 12 years. This frequency is substantially lower than that reported in Caucasian populations. The blast cells of the patients disclosed an early-B phenotype, displaying CD45, CD10 and CD19 antigens. The cytoplasmic granules were positive for the PAS reaction. Both patients died early after starting treatment; a poor prognosis has been recorded previously for patients with this type of malignancy.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalRevista de Investigacion Clinica
Issue number3
StatePublished - May 1997
Externally publishedYes


  • Acute leukemia
  • Early B leukemia
  • Hypergranular leukemia
  • Leukemia
  • Lymphoblastic leukemia


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