Utilidad de los ensayos de liberación de interferón gamma para la detección de tuberculosis en población pediátrica

Translated title of the contribution: Interferon gamma release assays for diagnosis of tuberculosis in pediatric population

Gerardo Álvarez-Hernández*, Jehan Bonizú Álvarez-Meza, María Del Carmen Candía-Plata, Enrique Bolado-Martínez, Miriam Denisse García-Villa, Manuel Alberto Cano-Rangel, María De Los Ángeles Durazo-Arvizu, Luis Fernando López-Soto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The interferon-gamma release assay (IGRA) is a novel method for the diagnosis of tuberculosis (TB), but its usefulness is uncertain in children. Objective: Examine the diagnostic capacity of QuantiFERON-TB Gold (QFT-G®) one of the IGRA commercial kits, in pediatric population of Sonora, Mexico. Methods: Cross-sectional design with 160 subjects less than 19 years old, in a hospital in Sonora, Mexico. Three groups were compared: one from patients with active TB (TBA), another one with latent TB (TBL) and one of hospital controls. The Stegen-Toledo criteria were the gold standard used. Multivariate logistic regression was performed to test the association between QFT-G® and selected predictors. Results: The sensitivity of QFT-G® in TBA was 76.9% and specificity 90.3%. For TBL, sensitivity was 25.0% and specificity of 98.6%. QFT-G® showed a moderate agreement (K = 0.574) with the standard. QFT-G® was associated with a chest radiograph suggestive of TB, (OR adjusted 4.37, 95% CI: 1.42, 13.42) and being a case of pulmonary TB (OR adjusted 6.15, 95% CI: 1.90, 19.92). Conclusion: The interferon-gamma release assay shows significant capacity to diagnose TBA and can be used to rule out TBL in the pediatric population.

Translated title of the contributionInterferon gamma release assays for diagnosis of tuberculosis in pediatric population
Original languageSpanish
Pages (from-to)442-455
Number of pages14
JournalActa Pediatrica de Mexico
Issue number6
StatePublished - 2015


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