PREGNANCY-INDUCED SHIFT IN CARDIAC METABOLISM SHIFT BY ACTIVATION OF HIF-1 AND TPPAR?

Detalles del proyecto

Descripción

Studies of reprogramming of cardiac metabolism involving HIF-1? and PPAR? activation will provide important new information that can potentially lead to the development of therapeutic tools for cardiovascular diseases such as hypertension, myocardial infarction, valvular heart disease and genetic mutations. Because cardiac hypertrophy has been considered as an important risk factor for cardiac morbidity and mortality whose prevalence has increased during last few decades, this study has the potential to directly address improved human health outcomes.

Objetivo general

The goal of this proposal is to evaluate the contributions of HIF-1? and PPAR? activation before, during, and after pregnancy to substrate metabolism in the left ventricle. The specific aims will address the central hypothesis that HIF-1? and PPAR? activation coordinate the reprogramming of cardiac metabolism during pregnancy, and that the HIF-1? and PPAR? activation is reversible during postpartum to coordinate the cellular metabolic response against hypertrophy.

Área de conocimiento

CIENCIAS DE LA VIDA

Disciplina

BIOQUÍMICA

Subdisciplina

NO APLICA

Sectores Beneficiados

CIENCIA Y TECNOLOGÍA

Naturaleza del proyecto

INTERDISCIPLINARIA

Ámbito de impacto

INTERNACIONAL

Tipo de cooperación con otras instituciones

INTERNACIONAL

Tipo de financiamiento

EXTERNO

Tipo de investigación

BÁSICA PURA
EstadoFinalizado
Fecha de inicio / finalización efectiva1/07/1431/12/15