Aging does not affect calcium response to CCL2 and LPS in human monocytes

Bruno de Jesús Arellano-Cruz, María de los Ángeles Vázquez-Prieto, Nilda Belén Fernández-Eufrasio, Dvorak Montiel-Condado, Genaro Patiño-López, Adriana Garibay-Escobar, Adriana Sumoza-Toledo*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Monocytes play important roles in anti-microbial and anti-viral responses and chronic inflammatory diseases. Monocytes' functions are altered by aging. We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. CCL2 and LPS induced a slow increase of the cytosolic Ca2+ level, with a maximum response at ∼360 s and ∼300 s, respectively, in monocytes of young and older adults. No difference was observed in the magnitude and in the Ca2+ kinetic with both stimuli. Furthermore, store-operated Ca2+ entry and plasma membrane expression of ORAI1 showed no difference between both groups. In summary, monocytes from older adults maintained the capacity to mobilize calcium as their counterparts in young adults suggesting that the mechanisms underlying the dysfunctions in monocytes in aging might not involve alterations in Ca2+ flow through the plasma membrane.

Idioma originalInglés
Páginas (desde-hasta)164-168
Número de páginas5
PublicaciónHuman Immunology
Volumen83
N.º2
DOI
EstadoPublicada - feb 2022

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© 2021 American Society for Histocompatibility and Immunogenetics

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