Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

Alex J. Salazar-Medina; Rocío Sugich-Miranda; Eli Teran-Cabanillas; Jesús Hernández; Gustavo A. González-Aguilar; Enrique Rudiño-Piñera; Rogerio R. Sotelo-Mundo; Enrique F. Velázquez-Contreras

doi:10.3390/molecules18021762

Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

Alex J. Salazar-Medina, Rocío Sugich-Miranda, Eli Teran-Cabanillas, Jesús Hernández, Gustavo A. González-Aguilar, Enrique Rudiño-Piñera, Rogerio R. Sotelo-Mundo, Enrique F. Velázquez-Contreras^*

^*Autor correspondiente de este trabajo

Departamento de Ciencias Químico-Biológicas

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

9 Citas (Scopus)

Resumen

The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe₂PO and Fe₂PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe₂PO and Fe₂PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.

Idioma original	Inglés
Páginas (desde-hasta)	1762-1774
Número de páginas	13
Publicación	Molecules
Volumen	18
N.º	2
DOI	https://doi.org/10.3390/molecules18021762
Estado	Publicada - feb. 2013

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@article{3bd3f7a87b584845a874ec4e0655ead4,

title = "Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes",

abstract = "The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.",

keywords = "Antioxidant, Biomimetic, Cyclophane, Iron, Macrocycle",

author = "Salazar-Medina, {Alex J.} and Roc{\'i}o Sugich-Miranda and Eli Teran-Cabanillas and Jes{\'u}s Hern{\'a}ndez and Gonz{\'a}lez-Aguilar, {Gustavo A.} and Enrique Rudi{\~n}o-Pi{\~n}era and Sotelo-Mundo, {Rogerio R.} and Vel{\'a}zquez-Contreras, {Enrique F.}",

year = "2013",

month = feb,

doi = "10.3390/molecules18021762",

language = "Ingl{\'e}s",

volume = "18",

pages = "1762--1774",

journal = "Molecules",

issn = "1420-3049",

number = "2",

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T1 - Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

AU - Salazar-Medina, Alex J.

AU - Sugich-Miranda, Rocío

AU - Teran-Cabanillas, Eli

AU - Hernández, Jesús

AU - González-Aguilar, Gustavo A.

AU - Rudiño-Piñera, Enrique

AU - Sotelo-Mundo, Rogerio R.

AU - Velázquez-Contreras, Enrique F.

PY - 2013/2

Y1 - 2013/2

N2 - The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.

AB - The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7, 10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo- 4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33- octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.

KW - Antioxidant

KW - Biomimetic

KW - Cyclophane

KW - Iron

KW - Macrocycle

UR - http://www.scopus.com/inward/record.url?scp=84874607188&partnerID=8YFLogxK

U2 - 10.3390/molecules18021762

DO - 10.3390/molecules18021762

M3 - Artículo

SN - 1420-3049

VL - 18

SP - 1762

EP - 1774

JO - Molecules

JF - Molecules

IS - 2

ER -

Antioxidant capacity of two novel bioactive Fe(III)-cyclophane complexes

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