Biocompatible silver nanoparticles synthesized using Rumex hymenosepalus extract decreases fasting glucose levels in diabetic rats

The objective of this study was to evaluate the antihyperglycemic activity of silver nanoparticles (SNPs) produced using green chemistry in a model of stretozotocin (STZ)-induced experimental diabetes in rats. Green SNPs (GSNPs) were synthesized using Rumex hymenosepalus extracts as reducing agent. In control and hyperglycemic rats was performed the measurement of blood glucose levels and glucose tolerance tests. Posteriorly, low dose of GSNPs were administrated in diabetic rats and was evaluated fasting blood glucose and glucose tolerance tests, pre and post-treatment. The basal level of fasting blood glucose of all rats (103.5 ± 4.4 mg/dL) increased after diabetes induction with STZ (315.2 ± 36.1 mg/dL). The treatment with GSNPs during 9 days decreased 50% the blood glucose in diabetic rats. The glucose tolerance test showed that in diabetic rats treated with GSNPs induces a minimal increase in blood glucose. In conclusion, a low dose of GSNPs showed antihyperglycemic activity.