Biocompatible silver nanoparticles synthesized using Rumex hymenosepalus extract decreases fasting glucose levels in diabetic rats

A. Virgen-Ortiz*, S. Limón-Miranda, M. A. Soto-Covarrubias, A. Apolinar-Iribe, E. Rodríguez-León, R. Iñiguez-Palomares

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

19 Citas (Scopus)

Resumen

The objective of this study was to evaluate the antihyperglycemic activity of silver nanoparticles (SNPs) produced using green chemistry in a model of stretozotocin (STZ)-induced experimental diabetes in rats. Green SNPs (GSNPs) were synthesized using Rumex hymenosepalus extracts as reducing agent. In control and hyperglycemic rats was performed the measurement of blood glucose levels and glucose tolerance tests. Posteriorly, low dose of GSNPs were administrated in diabetic rats and was evaluated fasting blood glucose and glucose tolerance tests, pre and post-treatment. The basal level of fasting blood glucose of all rats (103.5 ± 4.4 mg/dL) increased after diabetes induction with STZ (315.2 ± 36.1 mg/dL). The treatment with GSNPs during 9 days decreased 50% the blood glucose in diabetic rats. The glucose tolerance test showed that in diabetic rats treated with GSNPs induces a minimal increase in blood glucose. In conclusion, a low dose of GSNPs showed antihyperglycemic activity.

Idioma originalInglés
Páginas (desde-hasta)927-933
Número de páginas7
PublicaciónDigest Journal of Nanomaterials and Biostructures
Volumen10
N.º3
EstadoPublicada - 2015

Nota bibliográfica

Publisher Copyright:
© 2015,Inst Materials Physics. All rights reserved.

Huella

Profundice en los temas de investigación de 'Biocompatible silver nanoparticles synthesized using Rumex hymenosepalus extract decreases fasting glucose levels in diabetic rats'. En conjunto forman una huella única.

Citar esto