Biosynthesis of zinc oxide nanoparticles using Tamarix chinensis extract: evaluation of antioxidant, antimicrobial, and anti-MCF-7 cancer activities

Diego Carlos Bouttier-Figueroa*, Manuel Alfredo Loreto-Romero, Francisco Humberto González-Gutiérrez, Manuel Cortez-Valadez, Mario Flores-Acosta, Salvador Enrique Meneses-Sagrero, Ramón Enrique Robles-Zepeda*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

This study explores the green synthesis of zinc oxide nanoparticles (ZnONPs) using Tamarix chinensis extract, known for its hepatoprotective and anti-inflammatory phytochemicals. The ZnONPs were synthesized using ZnSO4 and NaOH, resulting in an average size of 125 nm, as confirmed by scanning electron microscopy (SEM). X-ray diffraction (XRD) analysis revealed a hexagonal crystalline structure. UV-Vis spectroscopy showed an absorption peak at 360 nm, corresponding to a bandgap of 3.37 eV, making these nanoparticles suitable for controlled drug delivery systems. The antioxidant activity of T. chinensis extract was evaluated using the DPPH assay, demonstrating an 80% inhibition of free radicals at 500 µg/mL, surpassing the antioxidant potential of the ZnONPs. The antimicrobial efficacy of the ZnONPs was evidenced by a minimum inhibitory concentration (MIC) of <50 µg/mL against Escherichia coli and Staphylococcus aureus. Additionally, the ZnONPs exhibited antiproliferative activity with an IC50 of 20.80 µg/mL in MCF-7 breast cancer cells, highlighting their potential for biomedical applications. These findings suggest the promising multifunctional role of biosynthesized ZnONPs in healthcare and technological innovations.

Idioma originalInglés
PublicaciónPreparative Biochemistry and Biotechnology
DOI
EstadoAceptada/en prensa - 2025

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