Calotropin and corotoxigenin 3-O-glucopyranoside from the desert milkweed Asclepias subulata inhibit the Na⁺/K⁺-ATPase activity

Agricultura y biología

• Asclepias 70%
• Apocynaceae 53%
• cardenolides 51%
• sodium-potassium-exchanging ATPase 48%
• deserts 43%
• digitoxin 14%
• cardioprotective agents 13%
• hydrophobic bonding 11%
• enzyme inhibition 10%
• in vivo studies 10%
• ouabain 10%
• assays 9%
• neoplasm cells 8%
• phytochemicals 8%
• inhibitory concentration 50 7%
• homeostasis 7%
• steroids 7%
• mechanism of action 7%
• cytotoxicity 7%
• binding sites 7%
• cell lines 6%
• ions 6%
• cells 5%
• amino acids 5%
• enzymes 4%

Medicina y ciencias biológicas

• calotropin 100%
• Asclepias 93%
• Cardenolides 63%
• sodium-translocating ATPase 50%
• Digitoxin 14%
• Cardiac Glycosides 12%
• Ouabain 10%
• Hydrophobic and Hydrophilic Interactions 10%
• Enzymes 10%
• Phytochemicals 9%
• Computer Simulation 8%
• Inhibitory Concentration 50 8%
• In Vitro Techniques 8%
• Ions 7%
• Binding Sites 7%
• Homeostasis 6%
• Amino Acids 6%
• Cell Line 5%
• Neoplasms 2%

Química

• Calotropin 95%
• Cardenolides 55%
• Cardenolide 19%
• Digitoxin 17%
• Cardiotonic Agent 17%
• Ouabain 14%
• Mammalian Cell 11%
• Antiproliferative 11%
• Steroid 10%
• Molecular Modeling 10%
• Amino-Acid Residue 10%
• Binding Site 8%
• Molecule 7%
• Ion 4%