TY - JOUR
T1 - Chemical polymerization of pyrrole in the presence of L-serine or L-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel
T2 - Electrically controlled amoxicillin release from composite hydrogel
AU - Castro, Leonardo Enrique Valencia
AU - Martínez, Cinthia Jhovanna Pérez
AU - Del Castillo Castro, Teresa
AU - Ortega, María Mónica Castillo
AU - Encinas, José Carmelo
N1 - Cited By :4
Export Date: 23 April 2019
CODEN: JAPNA
Correspondence Address: Del Castillo Castro, T.; Departamento de Investigación en Polímeros y Materiales, Universidad de SonoraMexico
Funding details: Consejo Nacional de Ciencia y Tecnología, CONACYT, 180280
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PY - 2015/1/1
Y1 - 2015/1/1
N2 - © 2014 Wiley Periodicals, Inc. Polypyrrole (PPy) was chemically prepared from aqueous solutions individually containing L-serine or L-glutamic acid, with the addition of ammonium persulfate as the oxidant. The electrical, XPS and FTIR characterizations indicated that the amino acids co-doped the PPy backbone. TEM revealed that PPy presented a quasi-spherical morphology with diameters in nanometric scale. The nanostructures of PPy-glutamic acid efficiently adsorbed therapeutic doses of amoxicillin. Composite hydrogels were obtained by the entrapment of amoxicillin-loaded PPy in polyacrylamide network. The antibiotic molecules can be subsequently released (or sustained) from composite hydrogel in response to application (or removal) of electrical stimulation. This tuning release profile can lead to promising drug delivery applications such as implantable devices and iontophoretic systems.
AB - © 2014 Wiley Periodicals, Inc. Polypyrrole (PPy) was chemically prepared from aqueous solutions individually containing L-serine or L-glutamic acid, with the addition of ammonium persulfate as the oxidant. The electrical, XPS and FTIR characterizations indicated that the amino acids co-doped the PPy backbone. TEM revealed that PPy presented a quasi-spherical morphology with diameters in nanometric scale. The nanostructures of PPy-glutamic acid efficiently adsorbed therapeutic doses of amoxicillin. Composite hydrogels were obtained by the entrapment of amoxicillin-loaded PPy in polyacrylamide network. The antibiotic molecules can be subsequently released (or sustained) from composite hydrogel in response to application (or removal) of electrical stimulation. This tuning release profile can lead to promising drug delivery applications such as implantable devices and iontophoretic systems.
KW - Conducting polymers
KW - Drug delivery systems
KW - Nanostructured polymers
KW - Amino acids
KW - Ammonium persulfate
KW - Drug delivery
KW - Implants (surgical)
KW - Polypyrroles
KW - Chemical polymerization
KW - Drug delivery applications
KW - Drug delivery system
KW - Electrical stimulations
KW - FT-IR characterization
KW - Implantable devices
KW - Spherical morphologies
KW - Hydrogels
UR - http://www.scopus.com/inward/record.url?scp=84926181406&partnerID=8YFLogxK
U2 - 10.1002/app.41804
DO - 10.1002/app.41804
M3 - Artículo
SN - 0021-8995
VL - 132
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 15
M1 - 41804
ER -