TY - JOUR
T1 - Cytotoxic activity of primulasaponin isolated from jacquinia macrocarpa cav. Spp. pungens (a. gray) b. ståhl
AU - Vidal Gutiérrez, Max
AU - Torres Moreno, Heriberto
AU - Jiménez-Estrada, Manuel
AU - Garibay Escobar, Adriana
AU - Velázquez Contreras, Carlos Arturo
AU - Robles-Zepeda, Ramón Enrique
N1 - Publisher Copyright:
© 2020, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.
PY - 2020/4/30
Y1 - 2020/4/30
N2 - Primulasaponin was isolated from the methanolic extract of the fruit shells of Jacquinia macrocarpa Cav. spp. pungens, and characterized by nuclear magnetic resonance (NMR) and mass spectrometry techniques. The evaluation of the cytotoxic activity was performed by the MTT cell proliferation assay using the cancer cell lines A549, LS180 and HeLa, and the non-cancerous cell line ARPE-19, obtaining the IC
50 of 13.6 µM, 9.3 µM, 23.5 µM, and 22.2 µM respectively. This is the first report of primulasaponin in the genus Jacquinia and its cytotoxic activity in cancer cell lines.
AB - Primulasaponin was isolated from the methanolic extract of the fruit shells of Jacquinia macrocarpa Cav. spp. pungens, and characterized by nuclear magnetic resonance (NMR) and mass spectrometry techniques. The evaluation of the cytotoxic activity was performed by the MTT cell proliferation assay using the cancer cell lines A549, LS180 and HeLa, and the non-cancerous cell line ARPE-19, obtaining the IC
50 of 13.6 µM, 9.3 µM, 23.5 µM, and 22.2 µM respectively. This is the first report of primulasaponin in the genus Jacquinia and its cytotoxic activity in cancer cell lines.
KW - Cytotoxic activity
KW - Jacquinia macrocarpa
KW - Primulasaponin
KW - Saponin
UR - https://pharmacologyonline.silae.it/files/archives/2020/vol1/PhOL_2020_1_A013_VidalGutierrez.pdf
UR - http://www.scopus.com/inward/record.url?scp=85089703291&partnerID=8YFLogxK
M3 - Artículo
SN - 1827-8620
VL - 1
SP - 121
EP - 128
JO - Pharmacologyonline
JF - Pharmacologyonline
ER -