TY - JOUR
T1 - Drug Resistance Analysis of Pathogens Isolated from Pediatric Patients in Mexico
AU - Cruz-López, Flora
AU - Rincón-Zuno, Joaquín
AU - Morfin-Otero, Rayo
AU - Rodríguez-Noriega, Eduardo
AU - Corte-Rojas, Reyna Edith
AU - Feliciano-Guzmán, José Manuel
AU - Gil-Veloz, Mariana
AU - Rodríguez-Muñoz, Lorena
AU - Choy-Chang, Elena Victoria
AU - Cetina-Umaña, Carlos Miguel
AU - Avilés-Benítez, Laura Karina
AU - Martínez-Meléndez, Adrián
AU - López-Jácome, Esaú
AU - Silva-Sánchez, Jesús
AU - Bolado-Martínez, Enrique
AU - López-García, Maribel
AU - Castañeda-Duarte, Juan De Dios
AU - Ramos-Medellin, Carmen Lucrecia
AU - Escalante-Armenta, Samuel Pavel
AU - Quintanilla-Cazares, Luis Javier
AU - Couoh-May, Carlos Antonio
AU - Quintana-Ponce, Sandra
AU - Newton-Sánchez, Oscar Alberto
AU - Rodriguez-Galicia, Verónica
AU - López-López, Dulce María
AU - Huirache-Villalobos, Guadalupe Soledad
AU - Ramirez-Mis, Jose Luis
AU - Rojas-Larios, Fabián
AU - Guerrero-Nuñez, Arely Elizabeth
AU - Zubiate-Tejada, Héctor Miguel
AU - Duarte-Miranda, Lizbeth Soraya
AU - Barroso-Herrera-Y-Cairo, Irma Elena
AU - Padilla-Rivas, Gerardo
AU - Garza-González, Elvira
N1 - Publisher Copyright:
© 2023 Georg Thieme Verlag. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Objective To analyze the resistance to antimicrobials in clinical isolates from pediatric patients in Mexico. Methods Susceptibility data from relevant specimens were collected in the pediatric population over 6 months from 25 centers from 17 states of Mexico and analyzed using the WHONET 5.6 software. Data were stratified into three age groups: younger than 2 years, 2 to 6 years, and 6 to 18 years. Results For Escherichia coli, the infant/toddler group had higher resistance rates to ampicillin, ampicillin-sulbactam, cefuroxime, cefepime, gentamicin, quinolones (p < 0.001), amoxicillin/clavulanic acid (p = 0.003), and ceftazidime (p = 0.004) than the other two age groups. Additionally, a high proportion of extended-spectrum β-lactamase (ESBL)-producing isolates for E. coli (75.3%) was detected in this age group. Comparable results were observed for Klebsiella pneumoniae, with higher resistance to ampicillin-sulbactam, ceftazidime, gentamicin, cefepime, trimethoprim-sulfamethoxazole, carbapenems (p = 0.001) and amoxicillin/clavulanic acid (p = 0.023) in the infant/toddler group. Moreover, a high proportion of ESBL producers (76%) was detected in this age group. Regarding wards, E. coli and K. pneumoniae had the highest carbapenem resistance in the ICU area, and Acinetobacter baumannii had the highest carbapenem resistance in medical wards. Conclusion High antibiotic resistance rates were detected in the infant/toddler group. This report presents baseline data for future prospective surveillance studies of antimicrobial resistance in pediatric patients in Mexico.
AB - Objective To analyze the resistance to antimicrobials in clinical isolates from pediatric patients in Mexico. Methods Susceptibility data from relevant specimens were collected in the pediatric population over 6 months from 25 centers from 17 states of Mexico and analyzed using the WHONET 5.6 software. Data were stratified into three age groups: younger than 2 years, 2 to 6 years, and 6 to 18 years. Results For Escherichia coli, the infant/toddler group had higher resistance rates to ampicillin, ampicillin-sulbactam, cefuroxime, cefepime, gentamicin, quinolones (p < 0.001), amoxicillin/clavulanic acid (p = 0.003), and ceftazidime (p = 0.004) than the other two age groups. Additionally, a high proportion of extended-spectrum β-lactamase (ESBL)-producing isolates for E. coli (75.3%) was detected in this age group. Comparable results were observed for Klebsiella pneumoniae, with higher resistance to ampicillin-sulbactam, ceftazidime, gentamicin, cefepime, trimethoprim-sulfamethoxazole, carbapenems (p = 0.001) and amoxicillin/clavulanic acid (p = 0.023) in the infant/toddler group. Moreover, a high proportion of ESBL producers (76%) was detected in this age group. Regarding wards, E. coli and K. pneumoniae had the highest carbapenem resistance in the ICU area, and Acinetobacter baumannii had the highest carbapenem resistance in medical wards. Conclusion High antibiotic resistance rates were detected in the infant/toddler group. This report presents baseline data for future prospective surveillance studies of antimicrobial resistance in pediatric patients in Mexico.
KW - antimicrobial resistance
KW - carbapenem-resistant Enterobacterales
KW - methicillin-resistant
KW - pediatric patients
UR - http://www.scopus.com/inward/record.url?scp=85168932515&partnerID=8YFLogxK
U2 - 10.1055/s-0043-1771528
DO - 10.1055/s-0043-1771528
M3 - Artículo
AN - SCOPUS:85168932515
SN - 1305-7707
JO - Journal of Pediatric Infectious Diseases
JF - Journal of Pediatric Infectious Diseases
ER -