TY - JOUR
T1 - Electrospun tubes based on PLA, gelatin and genipin in different arrangements for blood vessel tissue engineering
AU - Leyva-Verduzco, Abraham Alejandro
AU - Castillo-Ortega, María Mónica
AU - Chan-Chan, Lerma Hanaiy
AU - Silva-Campa, Erika
AU - Galaz-Méndez, Ramsés
AU - Vera-Graziano, Ricardo
AU - Encinas-Encinas, José Carmelo
AU - Del Castillo-Castro, Teresa
AU - Rodríguez-Félix, Dora Evelia
AU - Santacruz-Ortega, Hisila del Carmen
AU - Santos-Sauceda, Irela
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019
Y1 - 2019
N2 - Four tubular membranes based on PLA and gelatin with different arrangements (PLA, gelatin, PLA-gelatin Blend and PLA/gelatin Core/Shell) were prepared by the electrospinning technique, the gelatin within the materials was crosslinked with genipin and all the meshes were characterized by SEM, ATR-FTIR, TGA, DSC, XRD and mechanical tests, also a viability essay and a confocal microscopy of HUVECs in contact with the materials were carried out. A 50% decrement of cellular viability was observed in the fibers with Core/Shell structure since the first day of culture compared with the tissue culture polystyrene, due to solubilization of non-crosslinked gelatin.
AB - Four tubular membranes based on PLA and gelatin with different arrangements (PLA, gelatin, PLA-gelatin Blend and PLA/gelatin Core/Shell) were prepared by the electrospinning technique, the gelatin within the materials was crosslinked with genipin and all the meshes were characterized by SEM, ATR-FTIR, TGA, DSC, XRD and mechanical tests, also a viability essay and a confocal microscopy of HUVECs in contact with the materials were carried out. A 50% decrement of cellular viability was observed in the fibers with Core/Shell structure since the first day of culture compared with the tissue culture polystyrene, due to solubilization of non-crosslinked gelatin.
KW - Electrospinning
KW - Gelatin
KW - Poly(lactic acid)
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85076540731&partnerID=8YFLogxK
U2 - 10.1007/s00289-019-03057-7
DO - 10.1007/s00289-019-03057-7
M3 - Artículo
AN - SCOPUS:85076540731
SN - 0170-0839
VL - 77
SP - 5985
EP - 6003
JO - Polymer Bulletin
JF - Polymer Bulletin
IS - 11
ER -