TY - JOUR
T1 - Evidence for Human-to-Human Transmission of Hantavirus
T2 - A Systematic Review
AU - Toledo, Joao
AU - Haby, Michelle M.
AU - Reveiz, Ludovic
AU - Sosa Leon, Leopoldo
AU - Angerami, Rodrigo
AU - Aldighieri, Sylvain
N1 - Publisher Copyright:
© 2021 Pan American Health Organization. All rights reserved. The Pan American Health Organization has granted the Publisher permission for the reproduction of this article.
PY - 2022/10/15
Y1 - 2022/10/15
N2 - Background: Hantavirus is known to be transmitted from rodents to humans. However, some reports from Argentina and Chile have claimed that the hantavirus strain Andes virus (ANDV) can cause human-to-human transmission of the disease. The aim of this systematic review was to assess the evidence for human-to-human transmission of hantavirus. Methods: We searched PubMed (inception to 28 February 2021), Cochrane Central, Embase, LILACS and SciELO (inception to 3 July 2020), and other sources. We included studies that assessed whether interpersonal contact with a person with laboratory-confirmed hantavirus infection led to human-to-human transmission. Two reviewers conducted screening, selection, data extraction, and risk of bias assessment. Results: Twenty-two studies met the inclusion criteria. Meta-analysis was not possible due to heterogeneity. With the exception of 1 prospective cohort study of ANDV in Chile with serious risk of bias, evidence from comparative studies (strongest level of evidence available) does not support human-to-human transmission of hantavirus infection. Noncomparative studies with a critical risk of bias suggest that human-to-human transmission of ANDV may be possible. Conclusions: The balance of the evidence does not support the claim of human-to-human transmission of ANDV. Well-designed cohort and case-control studies that control for co-exposure to rodents are needed to inform public health recommendations.
AB - Background: Hantavirus is known to be transmitted from rodents to humans. However, some reports from Argentina and Chile have claimed that the hantavirus strain Andes virus (ANDV) can cause human-to-human transmission of the disease. The aim of this systematic review was to assess the evidence for human-to-human transmission of hantavirus. Methods: We searched PubMed (inception to 28 February 2021), Cochrane Central, Embase, LILACS and SciELO (inception to 3 July 2020), and other sources. We included studies that assessed whether interpersonal contact with a person with laboratory-confirmed hantavirus infection led to human-to-human transmission. Two reviewers conducted screening, selection, data extraction, and risk of bias assessment. Results: Twenty-two studies met the inclusion criteria. Meta-analysis was not possible due to heterogeneity. With the exception of 1 prospective cohort study of ANDV in Chile with serious risk of bias, evidence from comparative studies (strongest level of evidence available) does not support human-to-human transmission of hantavirus infection. Noncomparative studies with a critical risk of bias suggest that human-to-human transmission of ANDV may be possible. Conclusions: The balance of the evidence does not support the claim of human-to-human transmission of ANDV. Well-designed cohort and case-control studies that control for co-exposure to rodents are needed to inform public health recommendations.
KW - hantavirus
KW - hantavirus pulmonary syndrome
KW - healthcare-associated infections
KW - hemorrhagic fever with renal syndrome
KW - infectious disease transmission
KW - outbreak
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85119670503&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiab461
DO - 10.1093/infdis/jiab461
M3 - Artículo de revisión
C2 - 34515290
AN - SCOPUS:85119670503
SN - 0022-1899
VL - 226
SP - 1362
EP - 1371
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - 8
ER -