TY - JOUR
T1 - Fluorinated-NHC transition metal complexes
T2 - Leading characters as potential anticancer metallodrugs
AU - Rufino-Felipe, Ernesto
AU - Colorado-Peralta, Raúl
AU - Reyes-Márquez, Viviana
AU - Valdés, Hugo
AU - Morales-Morales, David
N1 - Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives, including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced biological properties and turning them into excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact on cancer treatment.
AB - In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives, including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced biological properties and turning them into excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact on cancer treatment.
KW - Cancer
KW - Cytotoxicity
KW - Fluorinated complexes
KW - Fluorine
KW - Metallodrugs
KW - N-heterocyclic carbene (NHC)
KW - NHC complexes
UR - http://www.scopus.com/inward/record.url?scp=85100376146&partnerID=8YFLogxK
U2 - 10.2174/1871520620666200908103452
DO - 10.2174/1871520620666200908103452
M3 - Artículo de revisión
C2 - 32900353
AN - SCOPUS:85100376146
SN - 1871-5206
VL - 21
SP - 938
EP - 948
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
IS - 8
ER -