Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery

A. M. Morales-Burgos*, E. Carvajal-Millan, N. Sotelo-Cruz, A. Rascón-Chu, J. Lizardi-Mendoza, Y. L. López-Franco, Marcel Martínez-Porchas, R. Canett-Romero

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

11 Citas (Scopus)

Resumen

In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.

Idioma originalInglés
Páginas (desde-hasta)16-22
Número de páginas7
PublicaciónEuropean Journal of Pharmaceutics and Biopharmaceutics
Volumen163
DOI
EstadoPublicada - jun. 2021

Nota bibliográfica

Publisher Copyright:
© 2021 Elsevier B.V.

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