HLA characterization in adult asymptomatic cyst passers of Entamoeba histolytica/E. dispar

Edith Valdez, Ma Del Carmen Martínez, Alejandro Gómez, Roberto Cedillo, Jorge Arellano, Marta E. Peŕez, Fernando Ramos, Patricia Morán, Enrique González, Olivia Valenzuela, Emma I. Melendro, Manuel Ramiro, Roberto Kretschmer, Onofre Muñoz, Cecilia Ximénez*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

8 Citas (Scopus)

Resumen

The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A, HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica/E. dispar adult cyst passers (cases) and a corresponding nonparasitized adult group (controls) followed for 12 months were identified. Entamoeba species were identified through zymodeme patterns and/or amplification of species-specific DNA sequences. A healthy, nonparasitized group of individuals was included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. These findings have to be added to previous results in which, in contrast to a demonstrated association between HLA-DR3 and amebic liver abscess in Mexican mestizo adults and infants, no significant association with amebic rectocolitis was found.

Idioma originalInglés
Páginas (desde-hasta)833-836
Número de páginas4
PublicaciónParasitology Research
Volumen85
N.º10
DOI
EstadoPublicada - 1999
Publicado de forma externa

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