Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment

Aaron Martínez-Higuera, César Rodríguez-Beas, Jesús Mauro Adolfo Villalobos-Noriega, Abraham Arizmendi-Grijalva, Carlos Ochoa-Sánchez, Eduardo Larios-Rodríguez, Juan Manuel Martínez-Soto, Ericka Rodríguez-León, Cristina Ibarra-Zazueta, Roberto Mora-Monroy, Hugo Alejandro Borbón-Nuñez, Alfonso García-Galaz, María del Carmen Candia-Plata, Luis Fernando López-Soto, Ramón Iñiguez-Palomares*

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

6 Citas (Scopus)

Resumen

In this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV–visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. The gels were characterized by UV–Vis, IR, and rheology. Antimicrobial tests were performed using Staphylococcus aureus and Escherichia coli. Burn wound healing was evaluated in a second-degree burn injury on a Wistar rats model for 14 days and additional skin biopsies were examined with histopathological analysis. Gel with commercial silver nanoparticles (Ag NPs) was prepared and employed as a control on the biological assays. Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area.

Idioma originalInglés
Número de artículo11312
PublicaciónScientific Reports
Volumen11
N.º1
DOI
EstadoPublicada - dic 2021
Publicado de forma externa

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Publisher Copyright:
© 2021, The Author(s).

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