Iron Carbide@Iron Oxide Core-Shell Nanoparticles Functionalization with L-Arginine Amphiphillic Bioconjugate

Paul Zavala Rivera, Jesús Armando Lucero Acuña, Patricia Guerrero Germán, Aaron de Jesús Rosas Durazo, Lizbeth Alcantara Bastida, Anya Isabel Argüelles Pesqueira*

*Autor correspondiente de este trabajo

Producción científica: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva


Metallic nanoparticles perform as therapeutic agents because of their precise response to optical, electrical, magnetic, physicochemical fields, and other stimulation processes at the nanometric scale. Targeted drug delivery using nanoparticles has been one of the most researched fields in recent years to improve the degree of precision, decrease treatment times, and reduce side effects compared to existing conventional methods. Nowadays, one nanoparticle synthesis and encapsulation process is improving green chemistry with surfactants conducive to increasing the biodegradability and biocompatibility of metal nanoparticles. Amino acid surfactants can provide functional groups with high affinity to the application site in drug delivery applications and reduce toxicity originating from the characteristic aggregation of metal nanoparticles. In that regard, functionalization by amino acids increases the use of metal nanoparticles. Arginine, as a surfactant in the nanometric scale and, at low concentrations, is used in cancer therapy, hormone deliberation, and drug delivery in biological systems. In this work, we evaluate polypeptides potentially used in various applications with metallic nanoparticles, such as separator agents in biological environments. Herein, oleic acid (OA) was bioconjugated with L-Arginine (OAR) to change iron carbide@ iron oxide nanoparticles (ICIONPs) core-shell type from hydrophobic to hydrophilic. The synthesis route is based on bioconjugation techniques, using N'N-Dicyclohexilcarbodimiide by nucleophilic substitution of the carboxyl group performed at low temperatures. This study shows OAR nanoparticles size 55 ± 24 nm of oleic acid.

Idioma originalInglés
Título de la publicación alojada45th Mexican Conference on Biomedical Engineering - Proceedings of CNIB 2022
EditoresCitlalli Jessica Trujillo-Romero, Rafael Gonzalez-Landaeta, Christian Chapa-González, Guadalupe Dorantes-Méndez, Dora-Luz Flores, J.J.Agustin Flores Cuautle, Martha R. Ortiz-Posadas, Ricardo A. Salido Ruiz, Esmeralda Zuñiga-Aguilar
EditorialSpringer Science and Business Media Deutschland GmbH
Número de páginas10
ISBN (versión impresa)9783031182556
EstadoPublicada - 2023
Evento45th Mexican Conference on Biomedical Engineering, CNIB 2022 - Puerto Vallarta, México
Duración: 6 oct. 20228 oct. 2022

Serie de la publicación

NombreIFMBE Proceedings
ISSN (versión impresa)1680-0737
ISSN (versión digital)1433-9277


Conferencia45th Mexican Conference on Biomedical Engineering, CNIB 2022
CiudadPuerto Vallarta

Nota bibliográfica

Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.


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