Legume proteins as a promising source of anti-inflammatory peptides

Aline Reyes-Díaz, Carmen Lizette Del-Toro-sánchez*, José Carlos Rodríguez-Figueroa, Santiago Valdez-Hurtado, Francisco Javier Wong-Corral, Jesús Borboa-Flores, María Fernanda González-Osuna, Liliana Maribel Perez-Perez, Ricardo Iván González-Vega

*Autor correspondiente de este trabajo

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

15 Citas (Scopus)


Legume proteins are precursors of bioactive components, such as peptides. In the present paper, different types of legume as sources of bioactive peptides and hydrolysates are considered and discussed based on their anti-inflammatory effect. Peptides with anti-inflammatory activity were included from in vitro and in vivo studies. Current strategies for obtaining bioactive peptides, as well as their structure and impact on health, were also reviewed. It was discovered that peptides derived from legume protein, mainly soybean and bean, can regulate several inflammatory markers, which include prosta-glandin E2 (PGE2), nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), cytokines, and chemokines. So far, lunasin, VPY and γ-glutamyl peptides have been identified with anti-inflammatory activity but their mechanisms have not been fully elucidated. Furthermore, it is necessary to gather more information about hydrolysates containing peptides and single peptides with anti-inflammatory activity. Considering the wide diversity, legume may be promising components to produce peptides efficient to ameliorate inflammatory disorders.

Idioma originalInglés
Páginas (desde-hasta)1204-1217
Número de páginas14
PublicaciónCurrent Protein and Peptide Science
EstadoPublicada - 2019

Nota bibliográfica

Funding Information:
We would like to thank Consejo Nacional de Ciencia y Tecnología (CONACYT) for the scholarship proportioned to Aline Reyes Díaz (CVU 328440). Additionally, we would like to thank M.C. Erick Gabriel Valenzuela Cruz for the figures edition of this review.

Publisher Copyright:
© 2019 Bentham Science Publishers.


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