TY - JOUR
T1 - Low number of peripheral blood B lymphocytes in patients with pulmonary tuberculosis
AU - Hernandez, Jesús
AU - Velazquez, Carlos
AU - Valenzuela, Olivia
AU - Robles-Zepeda, Ramón
AU - Ruiz-Bustos, Eduardo
AU - Navarro, Moisés
AU - Garibay-Escobar, Adriana
N1 - Funding Information:
This work was supported by Universidad de Sonora. The authors thank “Lab-oratorio Ramos” for the use of their flow cytometry unit.
PY - 2010
Y1 - 2010
N2 - The cellular immune response plays a critical role in the containment of persistent Mycobacterium tuberculosis infection; however, the immunological mechanisms that lead to its control are not completely identified. The goal of this study was to evaluate B (CD19+) and T (CD3+) peripheral blood lymphocyte profiles and T-cell subsets (CD4+ and CD8+) in patients with pulmonary tuberculosis (TB). Percentages (p = 0.02) and absolute numbers (p = 0.005) of B cells were significantly lower in patients with pulmonary TB than in healthy donors. In contrast, percentages (p = 0.12) and absolute numbers (p = 0.14) of T cells were similar in TB patients and healthy donors. No significant differences in percentages of CD4+ (p = 0.19) or CD8+ (p = 0.85) T cells between patients and healthy donors were observed. In summary, patients with pulmonary tuberculosis had a lower number of peripheral blood B lymphocytes than healthy controls.
AB - The cellular immune response plays a critical role in the containment of persistent Mycobacterium tuberculosis infection; however, the immunological mechanisms that lead to its control are not completely identified. The goal of this study was to evaluate B (CD19+) and T (CD3+) peripheral blood lymphocyte profiles and T-cell subsets (CD4+ and CD8+) in patients with pulmonary tuberculosis (TB). Percentages (p = 0.02) and absolute numbers (p = 0.005) of B cells were significantly lower in patients with pulmonary TB than in healthy donors. In contrast, percentages (p = 0.12) and absolute numbers (p = 0.14) of T cells were similar in TB patients and healthy donors. No significant differences in percentages of CD4+ (p = 0.19) or CD8+ (p = 0.85) T cells between patients and healthy donors were observed. In summary, patients with pulmonary tuberculosis had a lower number of peripheral blood B lymphocytes than healthy controls.
KW - B lymphocytes
KW - T lymphocytes
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=77950800695&partnerID=8YFLogxK
U2 - 10.3109/08820130903586346
DO - 10.3109/08820130903586346
M3 - Artículo
SN - 0882-0139
VL - 39
SP - 197
EP - 205
JO - Immunological Investigations
JF - Immunological Investigations
IS - 3
ER -