Magnetite Nanoparticles Functionalized with Vitamin E Analogues: Anticancer Effects

A. Angulo-Molina, M. A. Méndez-Rojas, T. Palacios-Hernández, O. E. Contreras-López, G. A. Hirata-Flores, J. C. Flores, K. L. Flores, C. Velázquez, R. Robles-Zepeda, E. Silva-Campa, A. Sarabia, M. Barboza-Flores, M. Pedroza-Montero, J. R. Reyes-Leyva, J. Hernández

Resultado de la investigación: Contribución a una conferenciaArtículo

2 Citas (Scopus)

Resumen

© 2016 Elsevier Ltd. Magnetite nanoparticles functionalized with alpha-tocopheryl succinate (Nps@α-TOS) increase anticancer activity of this vitamin E analogue. Previously, we reported Nps@α-TOS protect and enhance bioactivity of α-TOS in vitro. Nps@α-TOS selectively affected cervical cancer cells, without toxic effects for normal cells. The nanoparticles were internalized and accumulated around the nucleus. Severe morphological cell changes and lost viability were observed at 72 h post-treatment in contrast with non-effect in normal fibroblasts cells. These results suggested a cytotoxic effect in cancer cells and biocompatibility in normal cells. Further studies are needed in order to evaluate synergic anticancer bioactivity of Nps@α-TOS with other alternative treatments.
Idioma originalInglés estadounidense
Páginas703-707
Número de páginas5
DOI
EstadoPublicada - 1 ene 2016
EventoMaterials Today: Proceedings -
Duración: 1 ene 2016 → …

Conferencia

ConferenciaMaterials Today: Proceedings
Período1/01/16 → …

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