Mango “Ataulfo” Peel Extract Improves Metabolic Dysregulation in Prediabetic Wistar Rats

Alejandra M. Preciado-Saldaña, Jesús Abraham Domínguez-Avila, Jesús Fernando Ayala-Zavala, Humberto F. Astiazaran-Garcia, Marcelino Montiel-Herrera, Mónica A. Villegas-Ochoa, Gustavo A. González-Aguilar*, Abraham Wall-Medrano*

*Autor correspondiente de este trabajo

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

6 Citas (Scopus)


The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic ro-dents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory (α-amylase/α-glucosidase) activity. The polyphenolic MPE (138 mg EAG.g−1, mainly gallic acid and mangiferin) with antioxidant capacity (DPPH• 34 mgTE·g−1 ) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg·kg−1 ), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA-β) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract’s concentration–response in vitro enzyme inhibitory activity (IC50 ≈ 0.085 mg·mL−1 ). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes.

Idioma originalInglés
Número de artículo532
EstadoPublicada - abr. 2022

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


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