TY - JOUR
T1 - Mango “Ataulfo” Peel Extract Improves Metabolic Dysregulation in Prediabetic Wistar Rats
AU - Preciado-Saldaña, Alejandra M.
AU - Domínguez-Avila, Jesús Abraham
AU - Ayala-Zavala, Jesús Fernando
AU - Astiazaran-Garcia, Humberto F.
AU - Montiel-Herrera, Marcelino
AU - Villegas-Ochoa, Mónica A.
AU - González-Aguilar, Gustavo A.
AU - Wall-Medrano, Abraham
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4
Y1 - 2022/4
N2 - The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic ro-dents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory (α-amylase/α-glucosidase) activity. The polyphenolic MPE (138 mg EAG.g−1, mainly gallic acid and mangiferin) with antioxidant capacity (DPPH• 34 mgTE·g−1 ) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg·kg−1 ), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA-β) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract’s concentration–response in vitro enzyme inhibitory activity (IC50 ≈ 0.085 mg·mL−1 ). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes.
AB - The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic ro-dents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory (α-amylase/α-glucosidase) activity. The polyphenolic MPE (138 mg EAG.g−1, mainly gallic acid and mangiferin) with antioxidant capacity (DPPH• 34 mgTE·g−1 ) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg·kg−1 ), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA-β) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract’s concentration–response in vitro enzyme inhibitory activity (IC50 ≈ 0.085 mg·mL−1 ). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes.
KW - anti-diabetic effects
KW - byproducts
KW - mango peel
KW - phenolic compounds
KW - prediabetes
UR - http://www.scopus.com/inward/record.url?scp=85128486959&partnerID=8YFLogxK
U2 - 10.3390/life12040532
DO - 10.3390/life12040532
M3 - Artículo
C2 - 35455025
AN - SCOPUS:85128486959
SN - 2075-1729
VL - 12
JO - Life
JF - Life
IS - 4
M1 - 532
ER -