TY - JOUR
T1 - Nanocarriers as drug delivery systems for propolis
T2 - A therapeutic approach
AU - Mendez-Pfeiffer, Pablo
AU - Juarez, Josue
AU - Hernandez, Javier
AU - Taboada, Pablo
AU - Virués, Claudia
AU - Valencia, Dora
AU - Velazquez, Carlos
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/10
Y1 - 2021/10
N2 - Propolis is a resinous material produced by bees (Apis mellifera) from different botanical sources. It has a wide variety of biological activities attributed to its chemical constituents, which are mainly phenolic acids and polyphenols such as flavonoids. These components usually have low water solubility and poor bioavailability. Polymeric, lipid and inorganic nanocarriers had been mainly used as drug delivery systems to overcome the physiological limitations of propolis chemical constituents. This review covers recent research on different types of nanocarrier agents used to explore the delivery and therapeutic improvement of propolis extracts, as well as their physicochemical characterization and biological activities. Future studies should focus on understanding the chemical composition of propolis in association with nanosystems and how affects its encapsulation. Additionally, in vivo evaluations to assess the relevance of propolis associated to nanocarriers as therapeutic options are needed.
AB - Propolis is a resinous material produced by bees (Apis mellifera) from different botanical sources. It has a wide variety of biological activities attributed to its chemical constituents, which are mainly phenolic acids and polyphenols such as flavonoids. These components usually have low water solubility and poor bioavailability. Polymeric, lipid and inorganic nanocarriers had been mainly used as drug delivery systems to overcome the physiological limitations of propolis chemical constituents. This review covers recent research on different types of nanocarrier agents used to explore the delivery and therapeutic improvement of propolis extracts, as well as their physicochemical characterization and biological activities. Future studies should focus on understanding the chemical composition of propolis in association with nanosystems and how affects its encapsulation. Additionally, in vivo evaluations to assess the relevance of propolis associated to nanocarriers as therapeutic options are needed.
KW - Drug delivery systems
KW - Nanocarriers
KW - Propolis
KW - Propolis nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85111959011&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2021.102762
DO - 10.1016/j.jddst.2021.102762
M3 - Artículo de revisión
AN - SCOPUS:85111959011
SN - 1773-2247
VL - 65
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 102762
ER -